The modern patient is increasingly susceptible to bacterial infections including those due to
multidrug-resistant organisms (MDROs). Noninvasive whole-body analysis with pathogen-…

Tuberculous meningitis (TBM) is a devastating form of tuberculosis (TB), and key TB
antimicrobials, including rifampin, have restricted brain penetration. A lack of reliable data on …

Cavitation is a key pathological feature of human tuberculosis (TB), and is a well-recognized
risk factor for transmission of infection, relapse after treatment and the emergence of drug …

Bedaquiline is a promising drug against tuberculosis (TB), but limited data are available on
its intralesional pharmacokinetics. Moreover, current techniques rely on invasive tissue …

Post-surgical implant-associated spinal infection is a devastating complication commonly
caused by Staphylococcus aureus. Biofilm formation is thought to reduce penetration of …

Oxazolidinones are a novel class of antibacterials with excellent activity against resistant
Gram-positive bacteria including strains causing multidrug-resistant tuberculosis (TB). Despite …

Matrix metalloproteinases (MMPs) degrade extracellular matrix and are implicated in
tuberculosis pathogenesis and cavitation. In particular, MMP-7 is induced by hypoxia and highly …

Purpose Calcification is a hallmark of chronic tuberculosis (TB) in humans, often noted
years to decades (after the initial infection) on chest radiography, but not visualized well with …

para-Aminobenzoic acid (PABA) has been previously used as an exogenous marker to verify
completion of 24-h urine sampling. Therefore, we hypothesized that PABA radiolabeled …

Matrix metalloproteinase (MMP)-9 is a zinc-dependent protease associated with early
immune responses to Mycobacterium tuberculosis infection, macrophage recruitment and …