Background: A new oral pharmacokinetically enhanced formulation of the broad-spectrum
antibiotic amoxicillin/clavulanate has been developed to provide more effective therapy …

Antagonism of 5-hydroxytrypamine-6 (5HT6) receptors is associated with procognitive effects
in preclinical species, suggesting a therapeutic potential for this mechanism in Alzheimer …

OBJECTIVE: To establish the sensitivity and reliability of proximal interphalangeal (PIP) and
metacarpophalangeal (MCP) mean joint space measurements using standard clinical …

Aim: This Phase IV, double-blind, randomized, parallel-group study characterized the dose-response
and tolerability of fixed doses of ropinirole prolonged release (PR) in subjects with …

Gemifloxacin is a novel fluoroquinolone, currently in development for the treatment of respiratory
tract infections. This double-blind (with respect to gemifloxacin), randomized, crossover …

Gemifloxacin is a novel fluoroquinolone with a broad spectrum of activity. This double-blind,
randomized, parallel-group study was designed to demonstrate the lack of effect of steady-…

Aims To study the magnitude of differences in the pharmacokinetics of pranlukast, after
morning and evening administration. Methods Pranlukast (300 mg) was administered to 12 …

Purpose Coadministration of morphine with oral gabapentin has been shown to increase
plasma gabapentin concentrations. This study evaluated whether there was any interaction …

Background Gabapentin enacarbil (GEn) is a prodrug of gabapentin and is approved in the
United States in adults for the management of postherpetic neuralgia and in the United …

First‐time‐in‐human (FTIH) trials are designed to generate information on the safety, tolerability,
as well as the pharmacokinetic and pharmacodynamics profile of new drugs. To ensure …