Aggregation of alpha-synuclein (α-Syn) drives Parkinson’s disease (PD), although the initial
stages of self-assembly and structural conversion have not been directly observed inside …

Protein aggregation causes α-synuclein to switch from its physiological role to a pathological
toxic gain of function. Under physiological conditions, monomeric α-synuclein improves …

Protein aggregation and abnormal lipid homeostasis are both implicated in
neurodegeneration through unknown mechanisms. Here we demonstrate that aggregate-membrane …

Este artigo teve como ponto de partida o parecer que o Domínio de Matemática da Escola
Superior de Educação de Lisboa elaborou na fase de discussão pública da proposta de …

Este simpósio tem como objectivo apresentar e discutir estudos incidentes no ensino e na
aprendizagem da Geometria Começamos por clarificar alguns dos conceitos essenciais a …

Occupational mismatch has been a hot topic in the economics literature in recent decades;
however, no consensus has been reached on how to conceptualise and measure this …

The COVID-19 pandemic has forced many firms to close, causing an unprecedented interruption
in trade in most sectors of economic activity worldwide. Although global supply chains …

The discussion in recent years about the sustainability of the mining industry has emphasized
its commitment to social responsibility as an emerging topic. In this context, this article …

Despite the wealth of genomic and transcriptomic data in Parkinson’s disease (PD), the initial
molecular events are unknown. Using LD score regression analysis, we show significant …

O presente artigo apresenta parte de uma investigação desenvolvida com o objectivo de
analisar a construção do significado matemático, em interacção social, num ambiente …