We are developing assays for noninvasive, quantitative imaging of reporter genes with
positron emission tomography (PET), for application both in animal models and in human gene …

Herpes simplex virus type 1 (HSV-1) thymidine kinase is currently used as a suicide agent
in the gene therapy of cancer. This therapy is based on the preferential phosphorylation of …

Thermostabilizing an enzyme while maintaining its activity for industrial or biomedical
applications can be difficult with traditional selection methods. We describe a rapid computational …

Objective: To evaluate and summarize evidence of the effectiveness of interventions available
to public health staff that could be used to increase cervical cancer screening to women. …

Cancer suicide gene therapy affords the prospect of using the most optimal genes available
because the source of the therapeutic gene is often irrelevant. Currently, there are …

Agitated aggressive behavior in late stage dementia occurs in 30 to 50 percent of patients.
This behavior often results in the use of chemical and physical restraints (which have a high …

Cytosine deaminase (CD) catalyzes the deamination of cytosine, producing uracil. This enzyme
is present in prokaryotes and fungi (but not multicellular eukaryotes) and is an important …

Herpes Simplex Virus type 1 (HSV‐1) thymidine kinase (TK) is currently the most widely
used suicide agent for gene therapy of cancer. Tumor cells that express HSV‐1 thymidine …

Cytosine deaminase (CD) catalyzes the deamination of cytosine and is only present in
prokaryotes and fungi, where it is a member of the pyrimidine salvage pathway. The enzyme is of …

Osteocalcin (OC), a major noncollagenous bone matrix protein, is expressed prevalently in
prostate cancer epithelial cells, adjacent fibromuscular stromal cells, and osteoblasts in …