Hypertrophic cardiomyopathy (HCM) is an inherited disease of heart muscle that can be
caused by mutations in sarcomere proteins. Clinical diagnosis depends on an abnormal …

Imaging of somatostatin receptors (SSTRs) using [ 111 In]diethylenetriaminepentaacetic-acid-octreotide
(DTPAOC) has proven to be helpful in the differentiation of meningiomas, …

PURPOSE: [ 111 In]-DTPAOC (Octreoscan®) has been shown to be very useful in the
detection of somatostatin receptor (SSTR) positive tumors and their metastases using either …

We focus here on the modulation of thin filament activity by cardiac troponin I phosphorylation
as an integral and adaptive mechanism in cardiac homeostasis and as a mechanism …

Mutations in β-cardiac myosin, the predominant motor protein for human heart contraction,
can alter power output and cause cardiomyopathy. However, measurements of the intrinsic …

While significantly reduced glucose metabolism in fronto-temporo-parietal and cingulate
cortices has been demonstrated in Alzheimer's disease (AD) compared with controls, cerebral …

We have investigated cardiac myocytes derived from human-induced pluripotent stem cells (iPSC-CMs)
from two normal control and two family members expressing a mutant cardiac …

Aims Both left ventricular (LV) and left atrial (LA) dysfunction and remodelling contribute to
adverse outcomes in heart failure with reduced ejection fraction (HFrEF). Danicamtiv is a novel…

Rationale: Myofilament length-dependent activation (LDA) is the key underlying mechanism
of cardiac heterometric autoregulation, commonly referred as the Frank-Starling Law of the …

Purpose: To evaluate the influence of 68 -Ga-labeled DOTA ( 0 )-D-Phe ( 1 )-Tyr ( 3 )-Octreotide
positron emission tomography ([ 68 Ga]-DOTATOC-PET) for target definition for …