Acute myeloid leukemia (AML) is a devastating disease, with the majority of patients dying
within a year of diagnosis. For patients with relapsed/refractory AML, the prognosis is …

Despite the long‐known fact that the facilitative glucose transporter GLUT1 is one of the key
players safeguarding the increase in glucose consumption of many tumor entities even …

Neomorphic mutations in isocitrate dehydrogenase 1 (IDH1) are frequently found in several
human cancer types including acute myeloid leukemia (AML) and lead to the production of …

The lactate transporter SLC16A1/monocarboxylate transporter 1 (MCT1) plays a central role
in tumor cell energy homeostasis. In a cell-based screen, we identified a novel class of …

A continuous-flow process for the synthesis of triaminophloroglucinol has been developed.
The synthetic procedure is based on a sequential nitration/reduction protocol which uses …

Phenylalanyl (Phe)-tRNA synthetase (Phe-RS) is an essential enzyme which catalyzes the
transfer of phenylalanine to the Phe-specific transfer RNA (tRNA Phe ), a key step in protein …

Potent, selective and broadly characterized small molecule modulators of protein function (chemical
probes) are powerful research reagents. The pharmaceutical industry has …

Objectives The aim of this report was to characterize the key physicochemical, pharmacokinetic
(PK), and magnetic resonance imaging (MRI) properties of gadoquatrane (BAY 1747846)…

Avoidance of apoptosis is critical for the development and sustained growth of tumors. The
pro-survival protein myeloid cell leukemia 1 (Mcl-1) is an anti-apoptotic member of the Bcl-2 …

MTH1 is a hydrolase responsible for sanitization of oxidized purine nucleoside triphosphates
to prevent their incorporation into replicating DNA. Early tool compounds published in the …