The purpose of this study was to determine the clinical feasibility of diagnosing significant
coronary artery disease by positron imaging of myocardial perfusion without a cyclotron, using …

An efficient preparation of the hypoxic cell tracer [ 18 F]3-fluoro-1-(2′-nitro-1′-imidazolyl)-2-propanol
([ 18 F]fluoromisonidazole) is reported. This radiopharmaceutical is of interest to …

Rationale Variation in the rate at which drugs reach the brain influences many different drug
effects and is also thought to influence liability to addiction. For example, rapid intravenous …

Intrathecal (IT) delivery and pharmacology of antisense oligonucleotides (ASOs) for the
CNS have been successfully developed to treat spinal muscular atrophy. However, ASO …

Background Animals exposed to sevoflurane during development sustain neuronal cell
death in their developing brains. In vivo micro-positron emission tomography (PET)/computed …

Results Sulfate Synthesis. Surprisingly, 5"" 9 the direct reaction of cyclic diols with sulfuryl
chloride or diimidazolyl sulfate to produce bicyclic sulfates (9, 10, 14, 15) proceeded well. …

Although H 2 15 O is widely used for CBF measurement by positron tomography, it underestimates
CBF, especially at elevated flow rates. Several tracers, including butanol, overcome …

The utility of [ 18 F]fluoromethyl tosylate as an [ 18 F]fluoromethylation reagent has been
reexamined. The preparation of this potentially useful compound from the reaction of bis(…

A series of targets for production of fluorine-18 from enriched [ 18 O]water were constructed
using a double-foil design and silver spacers. The final target was provided standard with …

[ 18 F ]fluoroiodomethane was labeled via nucleophilic substitution of diiodomethane with [
18 F ]fluoride, and labeling conditions were optimized. The optimized labeling yield was 40±8…