Design and selection parameters to accelerate the discovery of novel central nervous system positron emission tomography (PET) ligands and their application in the …
To accelerate the discovery of novel small molecule central nervous system (CNS) positron
emission tomography (PET) ligands, we aimed to define a property space that would …
emission tomography (PET) ligands, we aimed to define a property space that would …
Stoichiometric and catalytic H/D incorporation by cationic iridium complexes: A common monohydrido-iridium intermediate
CM Yung, MB Skaddan… - Journal of the American …, 2004 - ACS Publications
A mechanistic study of the stoichiometric and catalytic H/D exchange reactions involving
cationic iridium complexes is presented. Strong evidence suggests that both stoichiometric and …
cationic iridium complexes is presented. Strong evidence suggests that both stoichiometric and …
Stoichiometric and catalytic deuterium and tritium labeling of “unactivated” organic substrates with cationic Ir (III) complexes
MB Skaddan, CM Yung, RG Bergman - Organic Letters, 2004 - ACS Publications
Ir(III) complex [Cp*(PMe 3 )IrMe(CH 2 Cl 2 )][BAr f ] (1) was used to introduce deuterium
stoichiometrically into substituted naphthalene/benzene templates and several “druglike” entities…
stoichiometrically into substituted naphthalene/benzene templates and several “druglike” entities…
One-pot synthesis of high molar activity 6-[18 F] fluoro-l-DOPA by Cu-mediated fluorination of a BPin precursor
…, JM Miller, BD Henderson, MB Skaddan… - Organic & …, 2019 - pubs.rsc.org
A one-pot two-step synthesis of 6-[18F]fluoro-L-DOPA ([18F]FDOPA) has been developed
involving Cu-mediated radiofluorination of a pinacol boronate ester precursor. The method is …
involving Cu-mediated radiofluorination of a pinacol boronate ester precursor. The method is …
Synthesis of high-molar-activity [18F]6-fluoro-l-DOPA suitable for human use via Cu-mediated fluorination of a BPin precursor
…, BD Henderson, T Erhard, C Bruetting, MB Skaddan… - Nature protocols, 2020 - nature.com
[ 18 F]6-fluoro-l-DOPA ([ 18 F]FDOPA) is a diagnostic radiopharmaceutical for positron emission
tomography (PET) imaging that is used to image Parkinson’s disease, brain tumors, and …
tomography (PET) imaging that is used to image Parkinson’s disease, brain tumors, and …
Synthesis and binding affinities of novel Re-containing 7α-substituted estradiol complexes: models for breast cancer imaging agents
MB Skaddan, FR Wüst… - The Journal of Organic …, 1999 - ACS Publications
The diagnosis and staging of breast cancer could be improved by the development of imaging
radiopharmaceuticals that provide a noninvasive determination of the estrogen receptor …
radiopharmaceuticals that provide a noninvasive determination of the estrogen receptor …
Pancreatic Beta Cell Mass PET Imaging and Quantification with [11C]DTBZ and [18F]FP-(+)-DTBZ in Rodent Models of Diabetes
Purpose The aim of this study is to compare the utility of two positron emission tomography (PET)
imaging ligands ((+)-[ 11 C]dihydrotetrabenazine ([ 11 C]DTBZ) and the fluoropropyl …
imaging ligands ((+)-[ 11 C]dihydrotetrabenazine ([ 11 C]DTBZ) and the fluoropropyl …
Radiochemical synthesis and tissue distribution of Tc-99m-labeled 7α-substituted estradiol complexes
MB Skaddan, FR Wüst, S Jonson, R Syhre… - Nuclear medicine and …, 2000 - Elsevier
The diagnosis and staging of breast cancer could be improved by the development of
radiopharmaceutical imaging agents that provide a noninvasive determination of the estrogen …
radiopharmaceutical imaging agents that provide a noninvasive determination of the estrogen …
The discovery of a novel phosphodiesterase (PDE) 4B-preferring radioligand for positron emission tomography (PET) imaging
…, RJ Mather, NC Patel, MB Skaddan… - Journal of Medicinal …, 2017 - ACS Publications
As part of our effort in identifying phosphodiesterase (PDE) 4B-preferring inhibitors for the
treatment of central nervous system (CNS) disorders, we sought to identify a positron emission …
treatment of central nervous system (CNS) disorders, we sought to identify a positron emission …
Radiolabeled Cholinesterase Substrates: In Vitro Methods for Determining Structure-Activity Relationships and Identification of a Positron Emission Tomography …
…, PS Sherman, ER Butch, MB Skaddan… - Journal of Cerebral …, 2001 - journals.sagepub.com
There is currently great interest in developing radiolabeled substrates for acetylcholinesterase
and butyrylcholinesterase that would be useful in the in vivo imaging of patients with …
and butyrylcholinesterase that would be useful in the in vivo imaging of patients with …