Survival of Homo sapiens during evolution was dependent on the procurement of food, which
in turn was dependent on physical activity. However, food supply was never consistent. …

A hypothesis is presented based on a coalescence of anthropological estimations of Homo
sapiens' phenotypes in the Late Paleolithic era 10,000 years ago, with Darwinian natural …

De novo lipogenesis is an energy-expensive process whose role in adult mammals is
poorly understood. We generated mice with liver-specific inactivation of fatty-acid synthase (FAS), …

The nuclear receptor PPARα is activated by drugs to treat human disorders of lipid metabolism.
Its endogenous ligand is unknown. PPARα-dependent gene expression is impaired with …

The current human genome was moulded and refined through generations of time. We
propose that the basic framework for physiologic gene regulation was selected during an era of …

Physical inactivity increases the risk of many chronic disorders. Numerous studies have
convincingly demonstrated that undertaking and maintaining moderate levels of physical activity …

One of the key factors responsible for the age-associated reduction in muscle mass may be
that satellite cell proliferation potential (number of doublings contained within each cell) …

Interest is growing in methods to extend replicative life span of non-immortalized stem cells.
Using the insulin-like growth factor I (IGF-I) transgenic mouse in which the IGF-I transgene is …

Central nervous system control of energy balance affects susceptibility to obesity and
diabetes, but how fatty acids, malonyl-CoA, and other metabolites act at this site to alter …

This report itemizes the costs and consequences of sedentary living, providing cost reasons
to fight a war on sedentary lifestyles. It begins by explaining that 70 percent of US adults are …