User profiles for Maneesh Jain

Maneesh Jain

Professor, University of Nebraska Medical Center
Verified email at unmc.edu
Cited by 16258

Tumour exosome integrins determine organotropic metastasis

…, MA Hollingsworth, M De Sousa, S Kaur, M Jain… - Nature, 2015 - nature.com
Ever since Stephen Paget’s 1889 hypothesis, metastatic organotropism has remained one
of cancer’s greatest mysteries. Here we demonstrate that exosomes from mouse and human …

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

…, PM Grandgenett, MA Hollingsworth, M Jain… - Nature cell …, 2015 - nature.com
Pancreatic ductal adenocarcinomas (PDACs) are highly metastatic with poor prognosis, mainly
due to delayed detection. We hypothesized that intercellular communication is critical for …

[PDF][PDF] Extracellular vesicle and particle biomarkers define multiple human cancers

…, M Berger, CM Rudin, DM Simeone, M Jain… - Cell, 2020 - cell.com
There is an unmet clinical need for improved tissue and liquid biopsy tools for cancer detection.
We investigated the proteomic profile of extracellular vesicles and particles (EVPs) in …

Targeting the EGFR signaling pathway in cancer therapy

…, MP Ponnusamy, D Haridas, M Jain… - Expert opinion on …, 2012 - Taylor & Francis
Introduction: Cancer is a devastating disease; however, several therapeutic advances have
recently been made, wherein EGFR and its family members have emerged as useful …

Electromagnetically induced transparency: propagation dynamics

A Kasapi, M Jain, GY Yin, SE Harris - Physical review letters, 1995 - APS
We describe the temporal and spatial dynamics of propagating electromagnetically induced
transparency pulses in an optically thick medium. Results include pulse velocities as slow …

Multiplexed genotyping with sequence-tagged molecular inversion probes

P Hardenbol, J Banér, M Jain, M Nilsson… - Nature …, 2003 - nature.com
We report on the development of molecular inversion probe (MIP) genotyping, an efficient
technology for large-scale single nucleotide polymorphism (SNP) analysis. This technique …

Efficient nonlinear frequency conversion with maximal atomic coherence

M Jain, H Xia, GY Yin, AJ Merriam, SE Harris - Physical review letters, 1996 - APS
We demonstrate efficient nonlinear frequency conversion in atomic Pb vapor under conditions
where the linear susceptibility and the effective nonlinear susceptibility are of the same …

Highly multiplexed molecular inversion probe genotyping: over 10,000 targeted SNPs genotyped in a single tube assay

…, R Fitzgerald, S Ghose, O Iartchouk, M Jain… - Genome …, 2005 - genome.cshlp.org
Large-scale genetic studies are highly dependent on efficient and scalable multiplex SNP
assays. In this study, we report the development of Molecular Inversion Probe technology with …

[HTML][HTML] RNA profiles reveal signatures of future health and disease in pregnancy

…, S Sazawal, RM Tribe, JM Roberts, M Jain… - Nature, 2022 - nature.com
Maternal morbidity and mortality continue to rise, and pre-eclampsia is a major driver of this
burden 1 . Yet the ability to assess underlying pathophysiology before clinical presentation …

Tumour extracellular vesicles and particles induce liver metabolic dysfunction

…, MA Hollingsworth, PM Grandgenett, M Jain… - Nature, 2023 - nature.com
Cancer alters the function of multiple organs beyond those targeted by metastasis 1 , 2 .
Here we show that inflammation, fatty liver and dysregulated metabolism are hallmarks of …