Artemisone—a highly active antimalarial drug of the artemisinin class

…, HD Heilmann, HW Chan, MK Cheung… - Angewandte Chemie …, 2006 - Wiley Online Library
The artemisinins are the most potent and rapidly acting antimalarial drugs. In response to
the global threat of multidrug-resistant malaria, they are now widely used in combination …

C‐10 Ester and Ether Derivatives of Dihydroartemisinin− 10‐α Artesunate, Preparation of Authentic 10‐β Artesunate, and of Other Ester and Ether Derivatives Bearing …

RK Haynes, HW Chan, MK Cheung… - European journal of …, 2002 - Wiley Online Library
Preparative and stereochemical aspects of reactions providing new C‐10 ester and ether
derivatives of the antimalarial drug dihydroartemisinin (DHA, 2) have been examined. β‐…

Reduced striatal dopamine transmission in REM sleep behavior disorder comorbid with depression

…, J Zhang, E Leung, CL Ho, S Chen, MK Cheung… - Neurology, 2015 - AAN Enterprises
Objective: To investigate dopamine transmission in patients with comorbid REM sleep
behavior disorder (RBD) and major depressive disorder (MDD). Methods: This is a case-control …

Dual-tracer PET/CT in renal angiomyolipoma and subtypes of renal cell carcinoma

…, YL Leung, KC Cheng, K Wong, M Cheung… - Clinical nuclear …, 2012 - journals.lww.com
We studied the metabolic characteristics of RCC subtypes and angiomyolipoma with 18 F-FDG
and 11 C-acetate PET/CT. Methods Fifty-eight patients with both baseline CT and dual-…

A simple, versatile, low-cost and remotely operated apparatus for [11C] acetate,[11C] choline,[11C] methionine and [11C] PIB synthesis

M Cheung, C Ho - Applied Radiation and Isotopes, 2009 - Elsevier
A simple, efficient and remotely operated synthesis apparatus for carrying out routine [ 11 C]carboxylation,
on-column and bubbling [ 11 C]methylation was essential for reliable, day-to-…

Stereoselective preparation of 10α‐and 10β‐aryl derivatives of dihydroartemisinin

RK Haynes, HW Chan, MK Cheung… - European journal of …, 2003 - Wiley Online Library
Lewis acid‐catalysed arylation of the 10β‐benzoate and, less effectively, the 10α‐benzoate
of dihydroartemisinin [DHA] with activated aromatic compounds, including naphthalenes, …

[18F]Fluoroacetate Positron Emission Tomography for Hepatocellular Carcinoma and Metastases: An Alternative Tracer for [11C]Acetate?

C Ho, M Cheung, S Chen, TT Cheung… - Molecular …, 2012 - journals.sagepub.com
[ 11 C]Acetate (ACT) positron emission tomography/computed tomography (PET/CT) is useful
in the detection of hepatocellular carcinoma (HCC). This study aimed to evaluate whether [ …

Syntheses of 6-Substituted Truncated Yuehchukene Analogues.

KF Cheng, MK Cheung, YC Kong - Australian journal of chemistry, 1997 - CSIRO Publishing
Facile syntheses of 2-t-butyl-3-(indol-3′-yl)-1, 2, 3, 4-tetrahydrocyclopent [b] indol-6-ol (3),
and its 6-methoxy (4) and 6-acetyloxy (5) derivatives are described.

Studies on the acid-catalyzed dimerization of 2-prenylindoles

V Lee, MK Cheung, WT Wong, KF Cheng - Tetrahedron, 1996 - Elsevier
Acid-catalyzed dimerization of 2-prenylindole derivatives 11, 16, and 27 have been examined.
While 2-dehydroprenylindole 11 underwent polymerization, alcohols 16 and 27 gave …

Cover Picture: Artemisone—A Highly Active Antimalarial Drug of the Artemisinin Class (Angew. Chem. Int. Ed. 13/2006)

…, HD Heilmann, HW Chan, MK Cheung… - Angewandte Chemie …, 2006 - Wiley Online Library
Qing hao su, or artemisinin, is the active compound isolated from the herb Artemisia annua (qīng
hāo) shown in the cover picture. The Chinese text shown describing its use in Chinese …