Background As the number of elderly people has increased in Japan, the occurrence of
aspiration pneumonia has also increased. Guidelines for the treatment of pneumonia have been …

The aim of this prospective study was to clarify whether dual-time-point 18 F-FDG PET
imaging results are useful to predict long-term survival of idiopathic pulmonary fibrosis (IPF) …

Background Hypoxia induces the proliferation of lung fibroblasts in vivo and in vitro. However,
the subcellular interactions between hypoxia and expression of tumor suppressor p53 and …

We report a case of acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) after pandemic
influenza (H1N1) vaccination. A 57-year-old man, who had been diagnosed with IPF in …

Background The early response to treatment with immune-checkpoint inhibitors is difficult to
evaluate. We determined whether changes in integrated [18 F]-fluoro-2-deoxy-D-glucose …

Background The p53 signaling pathway may be important for the pathogenesis of emphysematous
changes in the lungs of smokers. Polymorphism of p53 at codon 72 is known to affect …

Background Cigarette smoke induced oxidative stress has been shown to reduce silent
information regulator 1 (Sirt1) levels in lung tissue from smokers and patients with COPD patients…

Background Losing the sense of smell, which suggests eosinophilic rhinosinusitis, is a subjective
symptom, sometimes reported in asthmatic patients taking controller medication. Upper …

Background Anti-programmed death-1 (anti-PD-1) therapy has shown clinical success in
patients with advanced non-small cell lung cancer (NSCLC). However, it is difficult to evaluate …

Background Hypoxia induces the proliferation of pulmonary arterial smooth muscle cell (PASMC)
in vivo and in vitro, and prostacyclin analogues are thought to inhibit the growth of …