User profiles for Maciej S. Lesniak
Maciej S. LesniakProfessor of Neurosurgery Verified email at northwestern.edu Cited by 29211 |
Biofunctionalized magnetic-vortex microdiscs for targeted cancer-cell destruction
Nanomagnetic materials offer exciting avenues for probing cell mechanics and activating
mechanosensitive ion channels, as well as for advancing cancer therapies. Most experimental …
mechanosensitive ion channels, as well as for advancing cancer therapies. Most experimental …
Durable therapeutic efficacy utilizing combinatorial blockade against IDO, CTLA-4, and PD-L1 in mice with brain tumors
Purpose: Glioblastoma (GBM) is the most common form of malignant glioma in adults.
Although protected by both the blood–brain and blood–tumor barriers, GBMs are actively …
Although protected by both the blood–brain and blood–tumor barriers, GBMs are actively …
CCL2 produced by the glioma microenvironment is essential for the recruitment of regulatory T cells and myeloid-derived suppressor cells
In many aggressive cancers, such as glioblastoma multiforme, progression is enabled by
local immunosuppression driven by the accumulation of regulatory T cells (Treg) and myeloid-…
local immunosuppression driven by the accumulation of regulatory T cells (Treg) and myeloid-…
IDO expression in brain tumors increases the recruitment of regulatory T cells and negatively impacts survival
Purpose: Glioblastoma multiforme (GBM) is an aggressive adult brain tumor with a poor
prognosis. One hallmark of GBM is the accumulation of immunosuppressive and tumor-…
prognosis. One hallmark of GBM is the accumulation of immunosuppressive and tumor-…
[HTML][HTML] Chemokines in tumor progression and metastasis
PJ Sarvaiya, D Guo, I Ulasov, P Gabikian, MS Lesniak - Oncotarget, 2013 - ncbi.nlm.nih.gov
Chemokines play a vital role in tumor progression and metastasis. Chemokines are involved
in the growth of many cancers including breast cancer, ovarian cancer, pancreatic cancer, …
in the growth of many cancers including breast cancer, ovarian cancer, pancreatic cancer, …
[HTML][HTML] STING agonist-loaded, CD47/PD-L1-targeting nanoparticles potentiate antitumor immunity and radiotherapy for glioblastoma
As a key component of the standard of care for glioblastoma, radiotherapy induces several
immune resistance mechanisms, such as upregulation of CD47 and PD-L1. Here, leveraging …
immune resistance mechanisms, such as upregulation of CD47 and PD-L1. Here, leveraging …
Multifunctional nanoparticles for brain tumor imaging and therapy
Brain tumors are a diverse group of neoplasms that often carry a poor prognosis for patients.
Despite tremendous efforts to develop diagnostic tools and therapeutic avenues, the …
Despite tremendous efforts to develop diagnostic tools and therapeutic avenues, the …
Neural stem cell delivery of an oncolytic adenovirus in newly diagnosed malignant glioma: a first-in-human, phase 1, dose-escalation trial
Background Malignant glioma is the most common and lethal primary brain tumour, with
dismal survival rates and no effective treatment. We examined the safety and activity of NSC-…
dismal survival rates and no effective treatment. We examined the safety and activity of NSC-…
An increase in CD4+ CD25+ FOXP3+ regulatory T cells in tumor-infiltrating lymphocytes of human glioblastoma multiforme
AE Andaloussi, MS Lesniak - Neuro-oncology, 2006 - academic.oup.com
The subpopulation of CD4+CD25+ immunoregulatory T (Tr) cells constitutes 5%-10% of CD4+
cells in humans. These cells play a crucial role in the control of tumor immune response. …
cells in humans. These cells play a crucial role in the control of tumor immune response. …
A high-performance nanobio photocatalyst for targeted brain cancer therapy
We report pronounced and specific antiglioblastoma cell phototoxicity of 5 nm TiO 2 particles
covalently tethered to an antibody via a dihydroxybenzene bivalent linker. The linker …
covalently tethered to an antibody via a dihydroxybenzene bivalent linker. The linker …