User profiles for Maciej S. Lesniak

Maciej S. Lesniak

Professor of Neurosurgery
Verified email at northwestern.edu
Cited by 29211

Biofunctionalized magnetic-vortex microdiscs for targeted cancer-cell destruction

…, IV Ulasov, SD Bader, T Rajh, MS Lesniak… - Nature materials, 2010 - nature.com
Nanomagnetic materials offer exciting avenues for probing cell mechanics and activating
mechanosensitive ion channels, as well as for advancing cancer therapies. Most experimental …

Durable therapeutic efficacy utilizing combinatorial blockade against IDO, CTLA-4, and PD-L1 in mice with brain tumors

…, JW Kim, J Qiao, L Zhang, Y Han, MS Lesniak - Clinical cancer …, 2014 - AACR
Purpose: Glioblastoma (GBM) is the most common form of malignant glioma in adults.
Although protected by both the blood–brain and blood–tumor barriers, GBMs are actively …

CCL2 produced by the glioma microenvironment is essential for the recruitment of regulatory T cells and myeloid-derived suppressor cells

…, L Zhang, CM Horbinski, AU Ahmed, MS Lesniak - Cancer research, 2016 - AACR
In many aggressive cancers, such as glioblastoma multiforme, progression is enabled by
local immunosuppression driven by the accumulation of regulatory T cells (Treg) and myeloid-…

IDO expression in brain tumors increases the recruitment of regulatory T cells and negatively impacts survival

…, B Auffinger, AL Tobias, Y Han, MS Lesniak - Clinical cancer …, 2012 - AACR
Purpose: Glioblastoma multiforme (GBM) is an aggressive adult brain tumor with a poor
prognosis. One hallmark of GBM is the accumulation of immunosuppressive and tumor-…

[HTML][HTML] Chemokines in tumor progression and metastasis

PJ Sarvaiya, D Guo, I Ulasov, P Gabikian, MS Lesniak - Oncotarget, 2013 - ncbi.nlm.nih.gov
Chemokines play a vital role in tumor progression and metastasis. Chemokines are involved
in the growth of many cancers including breast cancer, ovarian cancer, pancreatic cancer, …

[HTML][HTML] STING agonist-loaded, CD47/PD-L1-targeting nanoparticles potentiate antitumor immunity and radiotherapy for glioblastoma

…, C Lee-Chang, J Miska, MS Lesniak - Nature …, 2023 - nature.com
As a key component of the standard of care for glioblastoma, radiotherapy induces several
immune resistance mechanisms, such as upregulation of CD47 and PD-L1. Here, leveraging …

Multifunctional nanoparticles for brain tumor imaging and therapy

…, B Auffinger, AL Tobias, MS Lesniak - Advanced drug delivery …, 2014 - Elsevier
Brain tumors are a diverse group of neoplasms that often carry a poor prognosis for patients.
Despite tremendous efforts to develop diagnostic tools and therapeutic avenues, the …

Neural stem cell delivery of an oncolytic adenovirus in newly diagnosed malignant glioma: a first-in-human, phase 1, dose-escalation trial

…, S Sachdev, KS Aboody, R Stupp, MS Lesniak - The Lancet …, 2021 - thelancet.com
Background Malignant glioma is the most common and lethal primary brain tumour, with
dismal survival rates and no effective treatment. We examined the safety and activity of NSC-…

An increase in CD4+ CD25+ FOXP3+ regulatory T cells in tumor-infiltrating lymphocytes of human glioblastoma multiforme

AE Andaloussi, MS Lesniak - Neuro-oncology, 2006 - academic.oup.com
The subpopulation of CD4+CD25+ immunoregulatory T (Tr) cells constitutes 5%-10% of CD4+
cells in humans. These cells play a crucial role in the control of tumor immune response. …

A high-performance nanobio photocatalyst for targeted brain cancer therapy

…, I Ulasov, B Lai, NM Dimitrijevic, MS Lesniak… - Nano …, 2009 - ACS Publications
We report pronounced and specific antiglioblastoma cell phototoxicity of 5 nm TiO 2 particles
covalently tethered to an antibody via a dihydroxybenzene bivalent linker. The linker …