Detection of Cell Death in Tumors by Using MR Imaging and a Gadolinium-based Targeted Contrast Agent1

AS Krishnan, AA Neves, MM de Backer, DE Hu… - Radiology, 2008 - pubs.rsna.org
Purpose: To prospectively determine in an animal model whether an ionic gadolinium (Gd 3+
) chelate conjugate of the C2A domain of synaptotagmin I can be used with magnetic …

Rapid imaging of tumor cell death in vivo using the C2A domain of Synaptotagmin-I

…, IS Alam, TH Witney, MM de Backer… - Journal of nuclear …, 2017 - Soc Nuclear Med
Cell death is an important target for imaging the early response of tumors to treatment. We
describe here the validation of a phosphatidylserine-binding agent for detecting tumor cell …

A paramagnetic nanoprobe to detect tumor cell death using magnetic resonance imaging

…, AS Krishnan, MI Kettunen, D Hu, MM de Backer… - Nano …, 2007 - ACS Publications
A 110 kDa (ca. 5 nm in diameter) bivalent paramagnetic nanoprobe for detecting cell death
using magnetic resonance imaging (MRI) is described, in which two biotinylated C2A …

Enhanced glutathione PEGylated liposomal brain delivery of an anti-amyloid single domain antibody fragment in a mouse model for Alzheimer's disease

…, MM Welling, A Bunschoten, ME de Backer… - Journal of Controlled …, 2015 - Elsevier
Abstract Treatment of neurodegenerative disorders such as Alzheimer's disease is hampered
by the blood–brain barrier (BBB). This tight cerebral vascular endothelium regulates …

The 1.9 Ć crystal structure of heat-labile shrimp alkaline phosphatase

M de Backer, S McSweeney, HB Rasmussen… - Journal of molecular …, 2002 - Elsevier
Alkaline phosphatases are non-specific phosphomonoesterases that are distributed widely
in species ranging from bacteria to man. This study has concentrated on the tissue-…

[HTML][HTML] In Vivo Detection of Amyloid-β Deposits Using Heavy Chain Antibody Fragments in a Transgenic Mouse Model for Alzheimer's Disease

…, MM Welling, A Metaxas, ME De Backer, M Rotman… - PLoS …, 2012 - journals.plos.org
This study investigated the in vivo properties of two heavy chain antibody fragments (V H H),
ni3A and pa2H, to differentially detect vascular or parenchymal amyloid-β deposits …

Ligand-binding and metal-exchange crystallographic studies on shrimp alkaline phosphatase

MME De Backer, S McSweeney, PF Lindley… - … Section D: Biological …, 2004 - scripts.iucr.org
Alkaline phosphatases (APs) are homodimeric metalloenzymes that catalyze the hydrolysis
and transphosphorylation of phosphate monoesters. Each monomer contains a metal-…

Characterization of image heterogeneity using 2D Minkowski functionals increases the sensitivity of detection of a targeted MRI contrast agent

…, AS Krishnan, AA Neves, M de Backer… - … in Medicine: An …, 2009 - Wiley Online Library
A targeted Gd 3+ ‐based contrast agent has been developed that detects tumor cell death
by binding to the phosphatidylserine (PS) exposed on the plasma membrane of dying cells. …

Polyfluorinated bis-styrylbenzenes as amyloid-β plaque binding ligands

…, A Metaxas, S de Jongh, M de Backer… - Bioorganic & Medicinal …, 2014 - Elsevier
Detection of cerebral β-amyloid (Aβ) by targeted contrast agents remains of great interest to
aid the in vivo diagnosis of Alzheimer’s disease (AD). Bis-styrylbenzenes have been …

Millisecond to microsecond time scale dynamics of the retinoid X and retinoic acid receptor DNA-binding domains and dimeric complex formation

…, FAA Mulder, MME de Backer, M Nair… - Biochemistry, 1999 - ACS Publications
The all-trans retinoic acid and 9-cis retinoic acid receptors (RAR and RXR, respectively)
belong to a family of ligand inducible transcription factors, which exert their effect via binding to …