Hypoxia and free radicals, such as reactive oxygen and nitrogen species, can alter the
function and/or activity of the transcription factor hypoxia-inducible factor 1 (HIF1). Interplay …

This paper is one of several in this Special Issue of the International Journal of Hyperthermia
that discusses the current state of knowledge about the human health risks of hyperthermia. …

The roles of nitric oxide (NO) in numerous disease states have generated considerable
discussion over the past several years. NO has been labeled as the causative agent in different …

Ionizing radiation represents the most effective therapy for glioblastoma (World Health
Organization grade IV glioma), one of the most lethal human malignancies 1 , but radiotherapy …

… This work was supported by grants from the NIH (CA40355 to MW Dewhirst, CA91565 to
MJ Kelley, and CA56690 to ML Wahl), by the Fonds de la Recherche Scientifique — Fonds …

This study was performed to explore the relationship between tumor oxygenation and
treatment outcome in human soft tissue sarcoma. Twenty-two patients with nonmetastatic, high-…

… anticancer efficacy than the low molecular weight drug alone ( 10 , 11 … molecular weight
and charge of the drug carrier. In this study, we focused on the influence of the molecular weight …

… approach by showing that films made from low-molecular-weight BF 2 dbm(I)PLA with
weak … fabricated from a higher-molecular-weight polymer with balanced fluorescence and …

… secondary to various complicated physiological responses (Dewhirst et al., 1990). Although
… tumors were treated after RT with a small molecular weight activation, we next sought to …

Purpose : Tumor hypoxia adversely affects short term clinical radiation response of head
and neck cancer lymph node metastases and long term disease-free survival (DFS) in cervix …