CD74: a new candidate target for the immunotherapy of B-cell neoplasms

R Stein, MJ Mattes, TM Cardillo, HJ Hansen… - Clinical Cancer …, 2007 - AACR
CD74 is an integral membrane protein that functions as a MHC class II chaperone. Moreover,
it has recently been shown to have a role as an accessory-signaling molecule and has …

Mouse strains with typical mammalian levels of complement activity

GL Ong, MJ Mattes - Journal of immunological methods, 1989 - Elsevier
Common laboratory mouse strains have very low complement levels relative to humans, rats,
guinea pigs, rabbits and other mammals, which limits the value of the mouse as an …

[PDF][PDF] The processing and fate of antibodies and their radiolabels bound to the surface of tumor cells in vitro: a comparison of nine radiolabels

…, HJ Hansen, DM Goldenberg, MJ Mattes - Journal of Nuclear …, 1994 - Soc Nuclear Med
MEI8Oand threeof the otherradiolabelswere also tested with this anbbody-targetcell
combinadonfor comparison. Results: Iodineconjugatedto antibOdieSby conventionalmethodswas …

Processing of antibody‐radioisotope conjugates after binding to the surface of tumor cells

M Jules Mattes, GL Griffiths, H Diril, DM Goldenberg… - cancer, 1994 - Wiley Online Library
Background. Previous experiments indicated that most antibodies binding to cell surface
antigens are internalized gradually and degraded within lysosomes, with a half‐life of …

The Fate of Antibodies Bound to the Surface of Tumor Cells in Vitro

…, LB Shih, GL Ong, K Patel, DM Goldenberg, MJ Mattes - Cancer research, 1992 - AACR
The fate of monoclonal antibodies binding to the surface of human tumor cells in vitro was
investigated. Seven antibodies, labeled with 125 I, were tested on four cell lines, which …

The Oka blood group antigen is a marker for the M6 leukocyte activation antigen, the human homolog of OX‐47 antigen, basigin and neurothelin, an immunoglobulin …

…, WJ Mawby, M Jules Mattes… - European journal of …, 1997 - Wiley Online Library
The high‐frequency blood group antigen Ok a is carried on a red cell membrane glycoprotein
(gp) of 35–69 kDa that is widely distributed on malignant cells of different origins. …

Advantage of residualizing radiolabels for an internalizing antibody against the B-cell lymphoma antigen, CD22

RM Sharkey, TM Behr, MJ Mattes, R Stein… - Cancer Immunology …, 1997 - Springer
LL2 is an anti-CD22 pan-B-cell monoclonal antibody which, when radiolabeled, has a high
sensitivity for detecting B-cell, non-Hodgkin’s lymphoma (NHL), as well as an antitumor …

Cure of SCID mice bearing human B-lymphoma xenografts by an anti-CD74 antibody-anthracycline drug conjugate

GL Griffiths, MJ Mattes, R Stein, SV Govindan… - Clinical Cancer …, 2003 - AACR
Purpose: The purpose of this research was to test the therapeutic efficacy of an
anthracycline-antibody conjugate for the treatment of human B-cell lymphoma in a preclinical animal …

Radionuclides linked to a CD74 antibody as therapeutic agents for B-cell lymphoma: comparison of Auger electron emitters with β-particle emitters

…, J Burton, G Sgouros, MJ Mattes - Journal of Nuclear …, 2000 - Soc Nuclear Med
We demonstrated previously that human B-cell lymphomas were effectively and specifically
killed in vitro by an antibody to CD74 (LL1) linked to 111 In or other Auger electron emitters. …

Rapid blood clearance of mouse IgG2a and human IgG1 in many nude and nu/+ mouse strains is due to low IgG2a serum concentrations

…, RM Sharkey, DM Goldenberg, MJ Mattes - Cancer immunology …, 1998 - Springer
We reported previously that the blood clearance of injected mouse IgG2a was extremely
rapid in many strains of nude and nu/+ mice. In an attempt to determine the cause of this …