C57BL/6J mice with a mutation in the obese (ob)gene are obese, diabetic, and exhibit reduced
activity, metabolism, and body temperature. Daily intraperitoneal injection of these mice …

THE hypothalamus plays a central role in the integrated regulation of energy homeostasis and
body weight, and a number of hypothalamic neuropeptides, such as neuropeptide Y (ref. 1…

The central meilanocortin system is critical for the long term regulation of energy homeostasis.
Null mutations of the melanocortin-4 receptor (MC4-R) are associated with hyperphagia, …

Background Paroxysmal nocturnal hemoglobinuria (PNH) arises from a somatic mutation of
the PIG-A gene in a hematopoietic stem cell and the subsequent production of blood cells …

Snake bite is often associated with localised soft tissue necrosis. Less frequently victims
may suffer extensive muscle damage leading to rhabdomyolysis and the loss of muscle-specific …

We reported earlier that the levels of Ca 2+ -dependent metalloproteinases are increased in
Alzheimer’s disease (AD) specimens, relative to control specimens. Here we show that …

There is evidence that central infusion of brain-derived neurotrophic factor (BDNF) induces
weight loss in rats. We have begun to investigate the physiological basis for BDNF-induced …

… to applied settings, such as admissions testing for higher education and employment
testing, though only a few studies to date have examined threat in applied testing settings (Cullen, …

Recently, a single gene, DYSF, has been identified which is mutated in patients with limb-girdle
muscular dystrophy type 2B (LGMD2B) and with Miyoshi myopathy (MM). This is of …

Despite overwhelming evidence that personality traits are useful pre—dictors of
counterproductive workplace behaviors (CWBs), little progress has been made in describing the …