Parkinson's disease is a neurodegenerative process characterized by numerous motor and
nonmotor clinical manifestations for which effective, mechanism-based treatments remain …

Parkinson disease is a complex, multifactorial neurodegenerative disease. Although a heritable
basis was originally thought unlikely, recent studies have implicated several genes in its …

Parkinson's disease (PD) is the most common motor neurodegenerative disease. Mutations
in the gene encoding leucine-rich repeat kinase 2 (LRRK2) have been linked recently with …

We examined a large family with autosomal dominant PD (average age of onset, 34 years),
ranging clinically from dementia with Lewy bodies to typical PD (3). Neuropathological …

… MC Chartier-Harlin and M Farrer designed and supervised the work and wrote the manuscript.
A Destée and P Amouyel helped coordinate the study. All investigators revised the report …

We have previously linked families with autosomal-dominant, late-onset parkinsonism to
chromosome 12p11.2-q13.1 (PARK8). By high-resolution recombination mapping and …

Background Recent studies indicate an increased frequency of mutations in the gene
encoding glucocerebrosidase (GBA), a deficiency of which causes Gaucher's disease, among …

The identification of genetic causes for Mendelian disorders has been based on the collection
of multi-incident families, linkage analysis, and sequencing of genes in candidate intervals…

Genomic triplication of the α‐synuclein gene recently has been associated with familial
Parkinson's disease in the Spellman–Muenter kindred. Here, we present an independent family, …

… Farrer has received speaker fees from Genetech and Teva; occasionally consults with Isis
Pharamaceuticals, H. Lundbeck A/S, and GlaxoSmithKline; receives royalties for patents held …