Monoclonal antibodies either of mouse, mouse/human chimeric, or human origin have been
used safely in human trials for a decade. Considerable effort has been committed in …

A mouse/human chimeric monoclonal antibody (mAb) composed of the variable regions of
murine 17-1A mAb and the constant regions of human IgG-1K immunoglobulin was …

PURPOSE: To evaluate the safety, pharmacokinetics, and efficacy of a chimeric anti–epidermal
growth factor receptor monoclonal antibody, cetuximab, in combination with radiation …

Gliomas are primary brain tumors that arise from differentiated glial cells through a poorly
understood malignant transformation. Although glioma cells retain some genetic and antigenic …

Purpose TM-601 binds to malignant brain tumor cells with high affinity and does not seem to
bind to normal brain tissue. Preclinical studies suggest that iodine-131 (131I)–TM-601 may …

The angiogenic response of a progressing malignancy is characterized by a shift in the balance
of stimulatory and inhibiting factors of angiogenesis. Recognition of the regulated steps …

Purpose: We investigated the expression of human endogenous retroviral (HERV) sequences
in breast cancer. Experimental Design: Reverse transcription-PCR (RT-PCR) was used to …

In a phase I trial, 12 patients with G D2 antigen-positive metastatic melanoma received the
murine anti-G D2 monoclonal antibody 14G2a. The monoclonal antibody was administered in …

Background.Twenty-seven ovarian cancer patients who failed chemotherapy entered a phase
I/II trial of intraperitoneal 177 Lu-CC49 antibody. Methods.Patients had disease confined …

The chimeric monoclonal anti-GD2 antibody ch14. 18 is made up of the variable region of
the murine anti-GD2 antibody 14.18 (or its IgG2a switch variant 14G2a) and the constant …