Mathematical modeling has played a prominent and necessary role in the current
coronavirus disease 2019 (COVID-19) pandemic, with an increasing number of models being …

Background A growing body of research has identified health-related quality-of-life effects
for caregivers and family members of ill patients (ie ‘spillover effects’), yet these are rarely …

Background. In 2008, the Institute of Medicine released a letter report identifying 4 research
priority areas for public health emergency preparedness in public health system research: (1…

In 2020, almost half a million individuals developed rifampicin-resistant tuberculosis (RR-TB).
We estimated the global burden of RR-TB over the lifetime of affected individuals. We …

Objective The worldwide pandemic involving the novel respiratory syndrome (COVID-19)
has forced health care systems to delay elective operations, including abdominal aortic …

Background Despite a consistent association with improved outcomes, public automated
external defibrillators (AEDs) are rarely used in out-of-hospital cardiac arrest. One of the …

Background: Gene therapy is a potential cure for sickle cell disease (SCD). Conventional
cost-effectiveness analysis (CEA) does not capture the effects of treatments on disparities in …

Background and study aims Given the sizable number of patients with symptomatic
gastroesophageal reflux disease (GERD) despite proton pump inhibitor (PPI) therapy, non-…

The objective was to assess the cost-effectiveness of staging PET/CT in early-stage follicular
lymphoma (FL) from the Canadian health-care system perspective. Methods: The study …

Background Emerging evidence suggests that shortened, simplified treatment regimens for
rifampicin-resistant tuberculosis (RR-TB) can achieve comparable end-of-treatment …