Upon illumination, photosensitizer molecules produce reactive oxygen species that can be
used for functional manipulation of living cells, including protein inactivation, targeted-…

P-selectin is an adhesion molecule translocated to the surface of endothelial cells and
platelets under inflammatory stimuli, and its potential as a biomarker in inflammatory conditions …

Pyridoxal phosphate (PLP)-dependent enzymes afford access to a variety of non-canonical
amino acids (ncAAs), which are premier building blocks for the construction of complex …

Agonist-promoted G-protein coupled receptor (GPCR) endocytosis and recycling plays an
important role in many signaling events in the cell. However, the approaches that allow fast …

Motile cilia project from the airway apical surface and directly interface with inhaled external
environment. Owing to cilia's nanoscale dimension and high beating frequency, quantitative …

Enzymes that bear a nonnative or artificially introduced metal center can engender novel
reactivity and enable new spectroscopic and structural studies. In the case of metal-organic …

Tryptamines are a medicinally important class of small molecules that serve as precursors
to more complex, clinically used indole alkaloid natural products. Typically, tryptamine …

Fluorescent protein-based pH sensors are useful tools for measuring protein trafficking
through pH changes associated with endo- and exocytosis. However, commonly used pH-…

In sickle cell disease (SCD), very late antigen-4 (VLA-4 or integrin α 4 β 1 ) mediates the
adhesion of reticulocytes to inflamed, proinflammatory endothelium, a key process in promoting …

A need in synthetic biology is the ability to precisely and efficiently make flexible fully
designed vectors that addresses challenging cloning strategies of single plasmids that rely on …