[HTML][HTML] STAT3/NF-κB-regulated lentiviral TK/GCV suicide gene therapy for cisplatin-resistant triple-negative breast cancer
WY Kuo, L Hwu, CY Wu, JS Lee, CW Chang, RS Liu - Theranostics, 2017 - ncbi.nlm.nih.gov
Triple-negative breast cancer (TNBC) represents approximately 20% of all breast cancers
and appears resistance to conventional cytotoxic chemotherapy, demonstrating a particularly …
and appears resistance to conventional cytotoxic chemotherapy, demonstrating a particularly …
[HTML][HTML] Enhancement of tumor initiation and expression of KCNMA1, MORF4L2 and ASPM genes in the adenocarcinoma of lung xenograft after vorinostat treatment
WY Kuo, CY Wu, L Hwu, JS Lee, CH Tsai, KP Lin… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Cancer stem cells (CSCs) are usually tolerant to chemotherapy and radiotherapy and
associated with tumor relapse. Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase …
associated with tumor relapse. Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase …
[HTML][HTML] Quantitative measurement of the thyroid uptake function of mouse by Cerenkov luminescence imaging
CC Ke, ZM He, YJ Hsieh, CW Huang, JJ Li, L Hwu… - Scientific reports, 2017 - nature.com
Cerenkov luminescence imaging (CLI) has been an evolutional and alternative approach of
nuclear imaging in basic research. This study aimed to measure the 131 I thyroid uptake of …
nuclear imaging in basic research. This study aimed to measure the 131 I thyroid uptake of …
[HTML][HTML] Detection of cancer stem cells by EMT-specific biomarker-based peptide ligands
YA Chen, CL Ho, MT Ku, L Hwu, CH Lu, SJ Chiu… - Scientific reports, 2021 - nature.com
The occurrence of epithelial-mesenchymal transition (EMT) within tumors, which enables
invasion and metastasis, is linked to cancer stem cells (CSCs) with drug and radiation …
invasion and metastasis, is linked to cancer stem cells (CSCs) with drug and radiation …
P21-driven multifusion gene system for evaluating the efficacy of histone deacetylase inhibitors by in vivo molecular imaging and for transcription targeting therapy of …
YJ Hsieh, L Hwu, YC Chen, CC Ke… - Journal of Nuclear …, 2014 - Soc Nuclear Med
Overexpressed histone deacetylase (HDAC) activity has been linked with tumor initiation
and progression that prompt the development of histone deacetylase inhibitors (HDACIs) as …
and progression that prompt the development of histone deacetylase inhibitors (HDACIs) as …
Production of type II ribotoxins by Aspergillus species and related fungi in Taiwan
A Lin, KC Huang, L Hwu, SS Tzean - Toxicon, 1995 - Elsevier
A molecular investigation was conducted on the production of type II ribotoxin of the species
Aspergillus and related fungi in Taiwan. Species that carried ribotoxin were confirmed by (1) …
Aspergillus and related fungi in Taiwan. Species that carried ribotoxin were confirmed by (1) …
The action mode of the ribosome-inactivating protein α-sarcin
L Hwu, KC Huang, DT Chen, A Lin - Journal of Biomedical Science, 2000 - Springer
Based on the tertiary structure of the ribosome-inactivating protein α-sarcin, domains that are
responsible for hydrolyzing ribosomes and naked RNA have been dissected. In this study, …
responsible for hydrolyzing ribosomes and naked RNA have been dissected. In this study, …
Specific activation of sodium iodide symporter gene in hepatoma using alpha-fetoprotein promoter combined with hepatitis B virus enhancer (EIIAPA)
RS Liu, YJ Hsieh, CC Ke, FD Chen, L Hwu… - Anticancer …, 2009 - ar.iiarjournals.org
Background: This study aimed to develop a novel tumor-specific promoter gene linking
sodium iodide symporter (NIS) gene to specifically target hepatocellular carcinoma in a mouse …
sodium iodide symporter (NIS) gene to specifically target hepatocellular carcinoma in a mouse …
Cre/loxP system controlled by specific promoter for radiation-mediated gene therapy of hepatoma
YJ Hsieh, RS Liu, L Hwu, CC Ke, FH Wang… - Anticancer …, 2007 - ar.iiarjournals.org
Background: To specifically target malignant cells, cancer gene therapy needs to combine
highly selective gene delivery with highly specific gene expression. In this study, hepatitis B …
highly selective gene delivery with highly specific gene expression. In this study, hepatitis B …
[HTML][HTML] Evaluation of lentiviral-mediated expression of sodium iodide symporter in anaplastic thyroid cancer and the efficacy of in vivo imaging and therapy
CC Ke, YJ Hsieh, L Hwu, FH Wang, FD Chen… - Journal of …, 2011 - hindawi.com
Anaplastic thyroid carcinoma (ATC) is one of the most deadly cancers. With intensive
multimodalities of treatment, the survival remains low. ATC is not sensitive to 131 I therapy due to …
multimodalities of treatment, the survival remains low. ATC is not sensitive to 131 I therapy due to …