Background: Several findings in humans support the hypothesis of links between n−3
polyunsaturated fatty acid (PUFA) status and psychiatric diseases. Objective: The involvement of …

We studied the effects of a diet chronically deficient in α-linolenic acid, the precursor of long-chain
n–3 polyunsaturated fatty acids, on dopaminergic neurotransmission in the shell …

More and more reports in recent years have shown that the intake of polyunsaturated fatty
acids (PUFA) constitutes an environmental factor able to act on the central nervous system (…

Small-animal positron emission tomography (PET) is a preclinical imaging method that uses
pharmacologically or biochemically active compounds labelled with short-lived positron-…

A general method for the α‐trifluoromethylthiolation of carbonyl compounds, without
prefunctionalization, has been developed. Aldehydes, ketones, esters, amides, keto‐esters, …

Pin the tail on the alkyne: CF3S‐or CF3CF2S‐alkynes can be simply and quickly obtained
by mixing terminal alkynes with a trifluoromethanesulfenamide reagent. The reaction uses …

The immune system plays a significant role in multiple sclerosis. While MS was historically
thought to be T cell-mediated, multiple pieces of evidence now support the view that B cells …

Because 5-HT 1A receptors located on the soma dendrites of serotonin (5-HT) neurons
normally mediate an inhibition of 5-HT firing and release, the desensitization of these …

Biased agonism (or “functional selectivity”) at G-protein-coupled receptors has attracted
rapidly increasing interest as a means to improve discovery of more efficacious and safer …

Neuroimaging of brain receptors began in the early 1980s. Now, some thirty-five years later,
PET imaging is still an expanding field of preclinical and clinical investigations. In addition to …