Oxygen tensions play an important role in the outcome of infections. Oxygen is cidal or static
for microorganisms that lack defenses against oxidants. Hyperoxia and hyperbaric oxygen …

Two human cell lysosomal membrane glycoproteins of ∼120 kDa, hLAMP-1 and hLAMP-2,
were identified by use of monoclonal antibodies prepared against U937 myelomonocytic …

The induction of autophagy caused by vinblastine (VBL) has been found to be concomitant
with a stimulation of proteolysis in a mitochondrial-lysosomal (ML) fraction from the rat liver (…

In 2007, the Food and Drug Administration requested that manufacturers of all approved
gadolinium-based contrast agents (GBCAs), drugs widely used in magnetic resonance imaging, …

Publisher Summary This chapter describes the mechanisms of intralysosomal degradation
with a special reference to autophagocytosis and heterophagocytosis of cell organelles. …

Cyclo-oxygenase inhibitors 1 and free-radical scavengers 2 protect the skin against necrosis
induced by frostbite. However, the tissue component (s) that determine the evolution of skin …

Free radicals and other toxic oxygen species play a role in the pathogenesis of ischemic
organ damage. The abdominal skin flap has been used as a model to study the effects of …

Frostbite is characterized by acute tissue injury induced by freezing and thawing. Initial
complete ischemia is followed by reperfusion and later, tissue necrosis. These vascular events …

Acrolein is a toxic metabolite of cyclophosphamide that causes hemorrhagic cystitis in 2 to
40% of treated patients. Hyperbaric oxygen (HBO) is used to treat poorly healing wounds in …

Isolated rat liver lysosomes were incubated with Percoll particles in vitro at 25 and 37 C. On
morphological examination the incubated lysosomes contain vesicles some of which …