Evaluation of 18F-RO-948 PET for quantitative assessment of tau accumulation in the human brain
…, K Kitmiller, J Roberts, L Gapasin… - Journal of Nuclear …, 2018 - Soc Nuclear Med
The availability of tau PET radioligands enables quantitative assessment of tau density and
distribution in the human brain. We evaluated the kinetics of a novel radioligand, 18 F-RO-…
distribution in the human brain. We evaluated the kinetics of a novel radioligand, 18 F-RO-…
Characterization of 3 novel tau radiopharmaceuticals, 11C-RO-963, 11C-RO-643, and 18F-RO-948, in healthy controls and in Alzheimer subjects
…, L Gobbi, G Klein, N George, L Gapasin… - Journal of Nuclear …, 2018 - Soc Nuclear Med
11 C-RO-963, 11 C-RO-643, and 18 F-RO-948 (previously referred to as 11 C-RO6924963,
11 C-RO6931643, and 18 F-RO6958948, respectively) have been reported as promising …
11 C-RO6931643, and 18 F-RO6958948, respectively) have been reported as promising …
[HTML][HTML] Dopamine D2 receptor occupancy of lumateperone (ITI-007): a Positron Emission Tomography Study in patients with schizophrenia
Dopamine D 2 receptor occupancy (D 2 RO) is a key feature of all currently approved
antipsychotic medications. However, antipsychotic efficacy associated with high D 2 RO is often …
antipsychotic medications. However, antipsychotic efficacy associated with high D 2 RO is often …
Human Brain Imaging of α7 nAChR with [18F]ASEM: a New PET Radiotracer for Neuropsychiatry and Determination of Drug Occupancy
…, Y Gao, H Valentine, A Nandi, L Gapasin… - Molecular imaging and …, 2014 - Springer
Purpose Using the α7-nAChR radiotracer, [ 18 F]ASEM, we present the first successful
human positron emission tomography (PET) studies. Rodent occupancy with three clinically …
human positron emission tomography (PET) studies. Rodent occupancy with three clinically …
Brain PET imaging of α7-nAChR with [18F] ASEM: reproducibility, occupancy, receptor density, and changes in schizophrenia
…, K Kitzmiller, JA Phan, L Gapasin… - International Journal …, 2018 - academic.oup.com
Background The α7 nicotinic acetylcholine receptor increasingly has been implicated in normal
brain physiology, as well as in neuropsychiatric disorders. The highly cortical distribution …
brain physiology, as well as in neuropsychiatric disorders. The highly cortical distribution …
ITI-007 demonstrates brain occupancy at serotonin 5-HT2A and dopamine D2 receptors and serotonin transporters using positron emission tomography in healthy …
Rationale Central modulation of serotonin and dopamine underlies efficacy for a variety of
psychiatric therapeutics. ITI-007 is an investigational new drug in development for treatment of …
psychiatric therapeutics. ITI-007 is an investigational new drug in development for treatment of …
First in-human PET study of 3 novel tau radiopharmaceuticals:[11C] RO6924963,[11C] RO6931643, and [18F] RO6958948
…, L Gobbi, G Klein, N George, L Gapasin… - Journal of Nuclear …, 2018 - Soc Nuclear Med
Background: [ 11 C]RO-963, [ 11 C]RO-643 and [ 18 F]RO-948 (previously referred as [ 11 C]RO6924963,
[ 11 C]RO6931643, and [ 18 F]RO6958948, respectively) have been reported …
[ 11 C]RO6931643, and [ 18 F]RO6958948, respectively) have been reported …
Role of partial volume correction in paired studies of C-11 PiB vs F-18 florbetapir: implications for centiloid?
…, N George, J Brasic, W Marashdeh, L Gapasin… - 2018 - Soc Nuclear Med
486 Objectives: PET imaging is significantly compromised by a number of resolution degrading
factors, resulting in undesirable cross-contamination between adjacent functional regions…
factors, resulting in undesirable cross-contamination between adjacent functional regions…
Comparison of [18F] D3FSP ([18F] P16-129) and [18F] AV45 in Alzheimer's Disease
1457 Objectives: We have synthesized and studied the deuterated N-methyl derivative of
Amyvid, [ 18 F]D3FSP ([ 18 F]P-16-129), in a pilot study in participants with Alzheimer’s disease …
Amyvid, [ 18 F]D3FSP ([ 18 F]P-16-129), in a pilot study in participants with Alzheimer’s disease …
[PDF][PDF] PET Brain imaging of α7-nAChR with [18F] ASEM
…, MD James Brasic, JAP BA, MS Lorena Gapasin… - researchgate.net
The α7 nicotinic acetylcholine receptor (nAChR) increasingly has been implicated in normal
brain physiology, as well as in neuropsychiatric disorders. The α7-nAChR primarily is …
brain physiology, as well as in neuropsychiatric disorders. The α7-nAChR primarily is …