Differences in sympathetic nervous stimulation of brown adipose tissue between the young and old, and the lean and obese

L Bahler, HJ Verberne, WM Admiraal… - Journal of Nuclear …, 2016 - Soc Nuclear Med
Brown adipose tissue (BAT) could facilitate weight loss by increasing energy expenditure.
Cold is a potent stimulator of BAT, activating BAT primarily through the sympathetic nervous …

Combining 123I-metaiodobenzylguanidine SPECT/CT and 18F-FDG PET/CT for the assessment of brown adipose tissue activity in humans during cold exposure

WM Admiraal, F Holleman, L Bahler… - Journal of Nuclear …, 2013 - Soc Nuclear Med
Brown adipose tissue (BAT) has become a focus of research in the hope of finding a new
target to fight obesity. Metabolic BAT activity can be visualized with 18 F-FDG PET/CT. …

Seasonal influence on stimulated BAT activity in prospective trials: a retrospective analysis of BAT visualized on 18F-FDG PET-CTs and 123I-mIBG SPECT-CTs

L Bahler, JW Deelen, JB Hoekstra… - Journal of Applied …, 2016 - journals.physiology.org
Retrospective studies have shown that outdoor temperature influences the prevalence of
detectable brown adipose tissue (BAT). Prospective studies use acute cold exposure to …

[HTML][HTML] Bromocriptine and insulin sensitivity in lean and obese subjects

L Bahler, HJ Verberne, E Brakema… - Endocrine …, 2016 - ncbi.nlm.nih.gov
Bromocriptine is a glucose-lowering drug, which was shown to be effective in obese
subjects with insulin resistance. It is usually administered in the morning. The exact working …

Metformin-related colonic glucose uptake; potential role for increasing glucose disposal?—A retrospective analysis of 18F-FDG uptake in the colon on PET–CT

L Bahler, K Stroek, JB Hoekstra, HJ Verberne… - Diabetes research and …, 2016 - Elsevier
Aim The use of metformin has been associated with diffusely increased colonic 18 F-fluorodeoxyglucose
( 18 F-FDG) uptake. Interestingly, metformin use is associated with moderate …

Hot heads & cool bodies: the conundrums of human brown adipose tissue (BAT) activity research

L Bahler, F Holleman, J Booij, JB Hoekstra… - European Journal of …, 2017 - Elsevier
Brown adipose tissue is able to increase energy expenditure by converting glucose and fatty
acids into heat. Therefore, BAT is able to increase energy expenditure and could thereby …

[HTML][HTML] 18F-FDG uptake in the colon is modulated by metformin but not associated with core body temperature and energy expenditure

L Bahler, F Holleman, MW Chan, J Booij, JB Hoekstra… - PLoS …, 2017 - journals.plos.org
Purpose Physiological colonic 18 F-fluorodeoxyglucose ( 18 F-FDG) uptake is a frequent
finding on 18 F-FDG positron emission tomography computed tomography (PET-CT). …

Interobserver and intraobserver variability for the assessment of brown adipose tissue activity on 18F-FDG PET-CT

L Bahler, F Holleman, J Booij, JB Hoekstra… - Nuclear Medicine …, 2016 - journals.lww.com
Objective Measurement of brown adipose tissue (BAT) activity is the focus of intensive research,
among others as a potential target for weight-lowering strategies. In this, BAT activity is …

Loss of sympathetic drive may explain loss of brown adipose tissue activity in elderly but not in obese males

L Bahler, W Admiraal, M Soeters, H Verberne… - 2014 - Soc Nuclear Med
1646 Objectives Metabolically active brown adipose tissue (BAT) could facilitate weight loss
by increasing energy expenditure. Cold is a potent stimulator of BAT, activating BAT …

[PDF][PDF] The influence of aspirin dose and glycaemic control on platelet inhibition in patients with type 2 diabetes

BA Lemkes, L Bähler, PW Kamphuisen… - Crossing borders: the …, 2011 - dare.uva.nl
Background Low-dose aspirin seems to offer no benefit in primary prevention of
cardiovascular disease in type 2 diabetes mellitus (DM2). The anti-platelet effect may be …