We have previously reported that cannabidiol (CBD) lowers the incidence of diabetes in
young non-obese diabetes-prone (NOD) female mice. In the present study we show that …

CXCR4 is a key player in the retention and survival of human acute myeloid leukemia (AML)
blasts in the bone marrow (BM) microenvironment. We studied the effects of the CXCR4 …

Inflammatory destruction of insulin-producing β cells in the pancreatic islets is the hallmark
of insulin-dependent diabetes mellitus, a spontaneous autoimmune disease of non-obese …

Background We assessed the mechanism by which multiple myeloma (MM) shapes the
bone marrow (BM) microenvironment and affects MΦ polarization. Methods In vivo xenograft …

The mechanism (s) that regulates NK cell mobilization and the significance of this process to
NK cell activity are unknown. After Con A-induced hepatitis, NK cells are mobilized from the …

Oral linomide, (quinoline-3-carboxamide), has been shown to prevent autoimmune insulitis,
islet destruction, and diabetes in NOD mice treated at an early stage of the disease, but …

Purpose: Chemokine axis CXCR4/CXCL12 is critically involved in the survival and
trafficking of normal and malignant B lymphocytes. Here, we investigated the effect of high-affinity …

CXCR4 expression in neuroblastoma tumors correlates with disease severity. In this study,
we describe mechanisms by which CXCR4 signaling controls neuroblastoma tumor growth …

In many pathological situations, tissue damage is caused by cellular generation of superoxide
free radicals (O 2 -). These active species are generated during post-ischemic reperfusion …

CD44 is a multistructural and multifunctional glycoprotein, the diversity of which is generated
by alternative splicing. In this communication we review some aspects related to CD44 …