Copper‐64‐alloyed gold nanoparticles for cancer imaging: improved radiolabel stability and diagnostic accuracy

Y Zhao, D Sultan, L Detering, S Cho, G Sun… - Angewandte …, 2014 - Wiley Online Library
Gold nanoparticles, especially positron‐emitter‐ labeled gold nanostructures, have gained
steadily increasing attention in biomedical applications. Of the radionuclides used for …

64Cu-Doped PdCu@Au Tripods: A Multifunctional Nanomaterial for Positron Emission Tomography and Image-Guided Photothermal Cancer Treatment

B Pang, Y Zhao, H Luehmann, X Yang, L Detering… - ACS …, 2016 - ACS Publications
This article reports a facile synthesis of radiolabeled PdCu@Au core–shell tripods for use in
positron emission tomography (PET) and image-guided photothermal cancer treatment by …

Molecular imaging visualizes recruitment of inflammatory monocytes and macrophages to the injured heart

…, G Bajpai, X Zhang, H Luehmann, L Detering… - Circulation …, 2019 - Am Heart Assoc
Rationale: Paradigm shifting studies have revealed that the heart contains functionally
diverse populations of macrophages derived from distinct embryonic and adult hematopoietic …

Facile synthesis, pharmacokinetic and systemic clearance evaluation, and positron emission tomography cancer imaging of 64 Cu–Au alloy nanoclusters

Y Zhao, D Sultan, L Detering, H Luehmann, Y Liu - Nanoscale, 2014 - pubs.rsc.org
Gold nanoparticles have been widely used for oncological applications including diagnosis
and therapy. However, the non-specific mononuclear phagocyte system accumulation and …

Gold Nanoclusters Doped with 64Cu for CXCR4 Positron Emission Tomography Imaging of Breast Cancer and Metastasis

Y Zhao, L Detering, D Sultan, ML Cooper, M You… - ACS …, 2016 - ACS Publications
As an emerging class of nanomaterial, nanoclusters hold great potential for biomedical
applications due to their unique sizes and related properties. Herein, we prepared a 64 Cu …

PET/CT imaging of chemokine receptor CCR5 in vascular injury model using targeted nanoparticle

HP Luehmann, ED Pressly, L Detering… - Journal of nuclear …, 2014 - Soc Nuclear Med
Inflammation plays important roles at all stages of atherosclerosis. Chemokine systems
have major effects on the initiation and progression of atherosclerosis by controlling the …

Gold Nanoparticles Doped with 199Au Atoms and Their Use for Targeted Cancer Imaging by SPECT

…, B Pang, H Luehmann, L Detering… - Advanced …, 2016 - Wiley Online Library
Gold nanoparticles have been labeled with various radionuclides and extensively explored
for single photon emission computed tomography (SPECT) in the context of cancer diagnosis…

CC chemokine receptor 2-targeting copper nanoparticles for positron emission tomography-guided delivery of gemcitabine for pancreatic ductal adenocarcinoma

X Zhang, L Detering, D Sultan, H Luehmann, L Li… - ACS …, 2021 - ACS Publications
Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy with dire prognosis due
to aggressive biology, lack of effective tools for diagnosis at an early stage, and limited …

PET/CT imaging of chemokine receptors in inflammatory atherosclerosis using targeted nanoparticles

HP Luehmann, L Detering, BP Fors… - Journal of nuclear …, 2016 - Soc Nuclear Med
Atherosclerosis is inherently an inflammatory process that is strongly affected by the
chemokine–chemokine receptor axes regulating the trafficking of inflammatory cells at all stages of …

Assessment of copper nanoclusters for accurate in vivo tumor imaging and potential for translation

…, Y Zhao, D Sultan, X Zhang, L Detering… - … applied materials & …, 2019 - ACS Publications
Nanoparticles have been widely used for preclinical cancer imaging. However, their successful
clinical translation is largely hampered by potential toxicity, unsatisfactory detection of …