[PDF][PDF] The processing and fate of antibodies and their radiolabels bound to the surface of tumor cells in vitro: a comparison of nine radiolabels

LB Shih, SR Thorpe, GL Griffiths, H Diril… - Journal of Nuclear …, 1994 - Soc Nuclear Med
MEI8Oand threeof the otherradiolabelswere also tested with this anbbody-targetcell
combinadonfor comparison. Results: Iodineconjugatedto antibOdieSby conventionalmethodswas …

Specificity and properties of MAb RS7‐3G11 and the antigen defined by this pancarcinoma monoclonal antibody

R Stein, A Basu, S Chen, LB Shih… - … journal of cancer, 1993 - Wiley Online Library
The murine monoclonal antibody (MAb) RS7‐3G11 is an IgG 1 with pancarcinoma reactivity,
which has been raised against human squamous‐cell carcinoma of the lung. Immunoperoxi…

The Fate of Antibodies Bound to the Surface of Tumor Cells in Vitro

RJ Kyriakos, LB Shih, GL Ong, K Patel, DM Goldenberg… - Cancer research, 1992 - AACR
The fate of monoclonal antibodies binding to the surface of human tumor cells in vitro was
investigated. Seven antibodies, labeled with 125 I, were tested on four cell lines, which …

Processing of antibody‐radioisotope conjugates after binding to the surface of tumor cells

…, H Diril, DM Goldenberg, GL Ong, LB Shih - cancer, 1994 - Wiley Online Library
Background. Previous experiments indicated that most antibodies binding to cell surface
antigens are internalized gradually and degraded within lysosomes, with a half‐life of …

Construction and characterization of a humanized, internalizing, B-cell (CD22)-specific, leukemia/lymphoma antibody, LL2

…, AS Dion, MC Pellegrini, J Shevitz, LB Shih… - Molecular …, 1995 - Elsevier
The murine monoclonal antibody, LL2, is a B-cell (CD22)-specific IgG2a which has been
demonstrated to be clinically significant in the radioimmunodetection of non-Hodgkin's B-cell …

In Vitro and in Vivo Reactivity of an Internalizing Antibody, RS7, with Human Breast Cancer

LB Shih, H Xuan, R Aninipot, R Stein, DM Goldenberg - Cancer Research, 1995 - AACR
RS7, a murine IgG1 antibody raised against human lung carcinoma, possesses pancarcinoma
reactivity. The antigen defined by this antibody is present in tumors of the lung, stomach, …

Advantage of residualizing radiolabels for an internalizing antibody against the B-cell lymphoma antigen, CD22

…, MJ Mattes, R Stein, GL Griffiths, LB Shih… - Cancer Immunology …, 1997 - Springer
LL2 is an anti-CD22 pan-B-cell monoclonal antibody which, when radiolabeled, has a high
sensitivity for detecting B-cell, non-Hodgkin’s lymphoma (NHL), as well as an antitumor …

Internalization of an intact doxorubicin immunoconjugate

LB Shih, DM Goldenberg, H Xuan, HWZ Lu… - Cancer Immunology …, 1994 - Springer
An immunoconjugate between doxorubicin and anti-(carcinoembryonic antigen) (CEA) was
prepared by using aminodextran (M r =40 000) as the intermediate carrier, and the …

Internalization and intracellular processing of an anti B‐cell lymphoma monoclonal antibody, ll2

LB Shih, HHZ Lu, H Xuan… - International journal of …, 1994 - Wiley Online Library
The successful clinical experience with antibody LL2 (an IgG 2a , anti‐B‐cell lymphoma
antibody) in radipimmunodetection and radioimmunotherapy suggests that this antibody may …

Anthracycline immunoconjugates prepared by a site-specific linkage via an amino-dextran intermediate carrier

LB Shih, DM Goldenberg, H Xuan, H Lu, RM Sharkey… - Cancer research, 1991 - AACR
Anthracycline, either daunomycin or doxorubicin, was site specifically attached to the
carbohydrate moiety of a monoclonal anticarcinoembryonic antigen antibody by using amino-…