Surveys and registries are needed to verify that real-life daily practice is in keeping with
what is recommended in the guidelines, thus completing the loop between clinical research, …

… Lionel Opie, who for more than 30 years has made original contributions to our … His fourth
edition of Heart Physiology: From Cell to Circulation demonstrates Professor Opie's broad and …

Ventricular remodelling describes structural changes in the left ventricle in response to chronic
alterations in loading conditions, with three major patterns: concentric remodelling, when …

Background Beta‐blockers refer to a mixed group of drugs with diverse pharmacodynamic
and pharmacokinetic properties. They have shown long‐term beneficial effects on mortality …

Remodelling is a response of the myocardium and vasculature to a range of potentially noxious
haemodynamic, metabolic, and inflammatory stimuli. Remodelling is initially functional, …

Although neurohumoral antagonism has successfully reduced heart failure morbidity and
mortality, the residual disability and death rate remains unacceptably high. Though …

Background— Hypertension in sub-Saharan Africa is a widespread problem of immense
economic importance because of its high prevalence in urban areas, its frequent …

… For such as these, Professor Lionel Opie has written the series of articles which begin on
the next page. As Professor Opie remarks, drugs should be given not because they ought to …

We review evidence for and against the ‘red wine hypothesis’, whereby red wine is more
likely to confer cardiovascular benefits than white. As background, there is a strong …

Objectives To test whether microalbuminuria in patients with type 2 diabetes and hypertension
is primarily dependent on the severity of hypertension, and to compare the effectiveness …