Probody Therapeutic Design of 89Zr-CX-072 Promotes Accumulation in PD-L1–Expressing Tumors Compared to Normal Murine Lymphoid Tissue
D Giesen, LN Broer, MN Lub-de Hooge, I Popova… - Clinical Cancer …, 2020 - AACR
Purpose: Probody therapeutic CX-072 is a protease-activatable antibody that is cross-reactive
with murine and human programmed death-ligand 1 (PD-L1). CX-072 can be activated in …
with murine and human programmed death-ligand 1 (PD-L1). CX-072 can be activated in …
89Zr-3, 2-HOPO-mesothelin antibody PET imaging reflects tumor uptake of mesothelin-targeted 227Th-conjugate therapy in mice
The mesothelin (MSLN)-targeted 227 Th conjugate is a novel α-therapy developed to treat
MSLN-overexpressing cancers. We radiolabeled the same antibody–chelator conjugate with …
MSLN-overexpressing cancers. We radiolabeled the same antibody–chelator conjugate with …
89Zr-labeled anti-PD-L1 Probody therapeutic CX-072 biodistribution in mice bearing human xenograft or murine syngeneic tumors
D Giesen, LN Broer, MNL Hooge, I Popova, B Howng… - Cancer Research, 2018 - AACR
BACKGROUND Immune checkpoint inhibiting antibodies have antitumor activity across several
tumor types, but are not effective in all patients and can elicit side effects. CX-072, a fully …
tumor types, but are not effective in all patients and can elicit side effects. CX-072, a fully …
Preclinical PET imaging of antibody therapies for cancer
L Broer - 2023 - research.rug.nl
… Preclinical PET imaging of antibody therapies for cancer Broer, Linda … to react with an 1:2
molar excess of tetrafluorphenolN-succinyldesferal (TFP-N-sucDf) (ABX GmbH) as described …
molar excess of tetrafluorphenolN-succinyldesferal (TFP-N-sucDf) (ABX GmbH) as described …
[PDF][PDF] Light-driven dynamic pattern formation de Jong, Jaap JD; Hania, P. Ralph; Pugzlys, Audrius; Lucas, Linda N.; de Loos, Maaike; Kellogg, Richard M.; Feringa, BL …
JJD De Jong - Angew. Chem. Int. Ed, 2005 - core.ac.uk
Dynamic self-assembly processes are essential for organization and various phenomena in
nature,[1] and mimicking of such processes in artificial systems offers fascinating …
nature,[1] and mimicking of such processes in artificial systems offers fascinating …
[HTML][HTML] Meta-analysis of telomere length in 19 713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect
… After meta-analysis, we found a significant association between paternal age and TL (n=5127;
β=0.005; P-value=7.01 × 10 −5 ). Maternal age was found to be significantly associated …
β=0.005; P-value=7.01 × 10 −5 ). Maternal age was found to be significantly associated …
GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy
L Broer, AS Buchman, J Deelen… - … Series A: Biomedical …, 2015 - academic.oup.com
Background. The genetic contribution to longevity in humans has been estimated to range
from 15% to 25%. Only two genes, APOE and FOXO3, have shown association with longevity …
from 15% to 25%. Only two genes, APOE and FOXO3, have shown association with longevity …
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk
…, MK Bolla, JS Brand, H Brauch, H Brenner, L Broer… - Nature …, 2017 - nature.com
The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated
with various adult diseases. Using 1000 Genomes Project–imputed genotype data in up to …
with various adult diseases. Using 1000 Genomes Project–imputed genotype data in up to …
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways
To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22
genome-wide association studies (GWAS) in 38,968 women of European descent, with …
genome-wide association studies (GWAS) in 38,968 women of European descent, with …
[HTML][HTML] A comparison of genotyping arrays
…, AG Uitterlinden, L Broer - European Journal of …, 2021 - nature.com
Array technology to genotype single-nucleotide variants (SNVs) is widely used in genome-wide
association studies (GWAS), clinical diagnostics, and linkage studies. Arrays have …
association studies (GWAS), clinical diagnostics, and linkage studies. Arrays have …