Glioblastoma is the most common primary malignant brain tumor in adults and is associated
with poor survival. The Ivy Foundation Early Phase Clinical Trials Consortium conducted a …

Purpose: We previously reported that autologous dendritic cells pulsed with acid-eluted tumor
peptides can stimulate T cell–mediated antitumor immune responses against brain tumors …

Mutations in the enzyme cytosolic isocitrate dehydrogenase 1 (IDH1) are a common feature
of a major subset of primary human brain cancers. These mutations occur at a single amino …

Cancer immunotherapy has made remarkable advances with over 50 separate Food and
Drug Administration (FDA) approvals as first- or second-line indications since 2015. These …

Background Optimum management of low-grade gliomas remains controversial, and widespread
practice variation exists. This evidence-based meta-analysis evaluates the association …

Background The epidermal growth factor receptor (EGFR) is frequently amplified, overexpressed,
or mutated in glioblastomas, but only 10 to 20 percent of patients have a response to …

Systematic efforts are underway to decipher the genetic changes associated with tumor
initiation and progression 1 , 2 . However, widespread clinical application of this information is …

While molecular subgrouping has revolutionized medulloblastoma classification, the extent
of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to …

Comprehensive knowledge of the genomic alterations that underlie cancer is a critical
foundation for diagnostics, prognostics, and targeted therapeutics. Systematic efforts to analyze …

Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated
with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive …