Nucleosomal fragmentation of DNA is a hallmark of apoptosis (programmed cell death) 1 ,
and results from the activation of nucleases in cells undergoing apoptosis. One such nuclease…

We report here the identification of a novel protein, Smac, which promotes caspase activation
in the cytochrome c/Apaf-1/caspase-9 pathway. Smac promotes caspase-9 activation by …

Background Both-bone diaphyseal forearm fractures constitute up to 5.4% of all fractures in
children in the United Kingdom. Most can be managed with closed reduction and cast …

Delay-tolerant networks (DTNs) have the potential to connect devices and areas of the world
that are under-served by current networks. A critical challenge for DTNs is determining …

We evaluated the safety, pharmacokinetic profile, pharmacodynamic effects, and antitumor
activity of abemaciclib, an orally bioavailable inhibitor of cyclin-dependent kinases (CDK) 4 …

Delayed Local Reactions to mRNA-1273 Vaccine Delayed cutaneous reactions developed
in 12 patients days after initial injection-related symptoms resolved. The reactions, some as …

Programmed cell death (apoptosis) is a tightly regulated process of cell disassembly in which
dying cells and their nuclei shrink and fragment and the chromosomal DNA is degraded …

Fungi are the principal degraders of biomass in most terrestrial ecosystems. In contrast to
surface environments, deep-sea environmental gene libraries have suggested that fungi are …

Background The Centers for Disease Control and Prevention state that a severe or immediate
allergic reaction to the first dose of an mRNA COVID-19 vaccine is a contraindication for …

Subjective Cognitive Decline (SCD) in older adults has been identified as a risk factor for
dementia, although the literature is inconsistent, and it is unclear which factors moderate …