Role of capsid structure and membrane protein processing in determining the size and copy number of peptides displayed on the major coat protein of filamentous …
…, SA Petukhov, MF Symmons, LC Welsh… - Journal of molecular …, 1996 - Elsevier
Filamentous bacteriophage virions can be engineered to display small foreign peptides in
the N-terminal regions of all 2700 copies of the major coat protein (pVIII), but larger peptides …
the N-terminal regions of all 2700 copies of the major coat protein (pVIII), but larger peptides …
[HTML][HTML] Normal tissue complication probability (NTCP) modelling using spatial dose metrics and machine learning methods for severe acute oral mucositis resulting …
JA Dean, KH Wong, LC Welsh, AB Jones… - Radiotherapy and …, 2016 - Elsevier
Background and purpose Severe acute mucositis commonly results from head and neck (chemo)radiotherapy.
A predictive model of mucositis could guide clinical decision-making and …
A predictive model of mucositis could guide clinical decision-making and …
[HTML][HTML] Non-coplanar trajectories to improve organ at risk sparing in volumetric modulated arc therapy for primary brain tumors
…, JC Bamber, HC Mandeville, LC Welsh… - Radiotherapy and …, 2016 - Elsevier
Background and purpose To evaluate non-coplanar volumetric modulated arc radiotherapy (VMAT)
trajectories for organ at risk (OAR) sparing in primary brain tumor radiotherapy. …
trajectories for organ at risk (OAR) sparing in primary brain tumor radiotherapy. …
[HTML][HTML] Changes in multimodality functional imaging parameters early during chemoradiation predict treatment response in patients with locally advanced head and …
…, A Dunlop, D Mcquaid, A Riddell, LC Welsh… - European journal of …, 2018 - Springer
Objective To assess the optimal timing and predictive value of early intra-treatment changes
in multimodality functional and molecular imaging (FMI) parameters as biomarkers for …
in multimodality functional and molecular imaging (FMI) parameters as biomarkers for …
[HTML][HTML] MRI-based assessment of 3D intrafractional motion of head and neck cancer for radiation therapy
…, D McQuaid, A Dunlop, KH Wong, LC Welsh… - International Journal of …, 2018 - Elsevier
Purpose To determine the 3-dimensional (3D) intrafractional motion of head and neck
squamous cell carcinoma (HNSCC). Methods and Materials Dynamic contrast-enhanced …
squamous cell carcinoma (HNSCC). Methods and Materials Dynamic contrast-enhanced …
The protein capsid of filamentous bacteriophage PH75 from Thermus thermophilus
DM Pederson, LC Welsh, DA Marvin… - Journal of Molecular …, 2001 - Elsevier
The PH75 strain of filamentous bacteriophage (Inovirus) grows in the thermophilic bacterium
Thermus thermophilus at 70 C. We have characterized the viral DNA and determined the …
Thermus thermophilus at 70 C. We have characterized the viral DNA and determined the …
[HTML][HTML] Structure of the capsid of Pf3 filamentous phage determined from X-ray fibre diffraction data at 3.1 Å resolution
LC Welsh, MF Symmons, JM Sturtevant… - Journal of molecular …, 1998 - Elsevier
We have recorded X-ray diffraction patterns at 3.1 Å resolution from magnetically aligned
fibres of the Pf3 strain of filamentous bacteriophage (Inovirus). The patterns are similar to …
fibres of the Pf3 strain of filamentous bacteriophage (Inovirus). The patterns are similar to …
The molecular structure and structural transition of the α-helical capsid in filamentous bacteriophage Pf1
LC Welsh, MF Symmons, DA Marvin - Acta Crystallographica Section …, 2000 - scripts.iucr.org
The major coat protein in the capsid of Pf1 filamentous bacteriophage (Inovirus) forms a
helical assembly of about 7000 identical protein subunits, each of which contains 46 amino-acid …
helical assembly of about 7000 identical protein subunits, each of which contains 46 amino-acid …
[HTML][HTML] A novel method for delineation of oral mucosa for radiotherapy dose–response studies
JA Dean, LC Welsh, SL Gulliford, KJ Harrington… - Radiotherapy and …, 2015 - Elsevier
There is currently no standard method for delineating the oral mucosa and most attempts are
oversimplified. A new method to obtain anatomically accurate contours of the oral mucosa …
oversimplified. A new method to obtain anatomically accurate contours of the oral mucosa …
[HTML][HTML] Functional data analysis applied to modeling of severe acute mucositis and dysphagia resulting from head and neck radiation therapy
JA Dean, KH Wong, H Gay, LC Welsh, AB Jones… - International Journal of …, 2016 - Elsevier
Purpose Current normal tissue complication probability modeling using logistic regression
suffers from bias and high uncertainty in the presence of highly correlated radiation therapy (…
suffers from bias and high uncertainty in the presence of highly correlated radiation therapy (…