Background To comprehend the results of diagnostic accuracy studies, readers must understand
the design, conduct, analysis, and results of such studies. That goal can be achieved …

Incomplete reporting has been identified as a major source of avoidable waste in biomedical
research. Essential information is often not provided in study reports, impeding the …

The quality of reporting of studies of diagnostic accuracy is less than optimal. Complete and
accurate reporting is necessary to enable readers to assess the potential for bias in the …

BACKGROUND AND OBJECTIVE: Publication bias and other sample size effects are issues
for meta-analyses of test accuracy, as for randomized trials. We investigate limitations of …

Diagnostic accuracy studies are, like other clinical studies, at risk of bias due to shortcomings
in design and conduct, and the results of a diagnostic accuracy study may not apply to …

… Les Irwig was the author of the original review and provided comments on the updated …
Glasziou PP, Irwig LM. An evidence based approach to individualising treatment. BMJ 1995;311:…

Meta‐analyses are subject to bias for many of reasons, including publication bias. Asymmetry
in a funnel plot of study size against treatment effect is often used to identify such bias. We …

A literature search identified 62 studies published by August 1992 comparing Papanicolaou
(Pap) test results with histology. Critical appraisal revealed that 82% of these had potential …

Objectives: To introduce guidelines for the conduct, reporting, and critical appraisal of meta-analyses
evaluating diagnostic tests and to apply these guidelines to recently published meta…

Background Colorectal cancer is a leading cause of morbidity and mortality, especially in
the Western world. The human and financial costs have prompted considerable research to …