User profiles for Leo Flores

Leonardo L Flores

Professor and Chair, Department of English, Appalachian State University
Verified email at upr.edu
Cited by 161

[HTML][HTML] The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis

…, SW Lee, Z Feng, HY Huang, KKC Tsai, LG Flores… - Cell, 2012 - cell.com
Akt kinase plays a central role in cell growth, metabolism, and tumorigenesis. The TRAF6
E3 ligase orchestrates IGF-1-mediated Akt ubiquitination and activation. Here, we show that …

Tumor Site–Specific Silencing of NF-κB p65 by Targeted Hollow Gold Nanosphere–Mediated Photothermal Transfection

W Lu, G Zhang, R Zhang, LG Flores, Q Huang… - Cancer research, 2010 - AACR
NF-κB transcription factor is a critical regulator of the expression of genes involved in tumor
formation and progression. Successful RNA interference (RNAi) therapeutics targeting NF-κB …

Effects of photoacoustic imaging and photothermal ablation therapy mediated by targeted hollow gold nanospheres in an orthotopic mouse xenograft model of glioma

…, Q Huang, A Elliott, S Song, R Zhang, LG Flores… - Cancer research, 2011 - AACR
Advancements in nanotechnology have made it possible to create multifunctional nanostructures
that can be used simultaneously to image and treat cancers. For example, hollow gold …

[HTML][HTML] Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma

…, S Soghomonyan, LG Flores… - The Journal of …, 2011 - Am Soc Clin Investig
The management of CNS tumors is limited by the blood-brain barrier (BBB), a vascular interface
that restricts the passage of most molecules from the blood into the brain. Here we show …

Molecular imaging of active mutant L858R EGF receptor (EGFR) kinase-expressing nonsmall cell lung carcinomas using PET/CT

…, A Shavrin, S Soghomonyan, L Flores… - Proceedings of the …, 2011 - National Acad Sciences
The importance of the EGF receptor (EGFR) signaling pathway in the development and
progression of nonsmall cell lung carcinomas (NSCLC) is widely recognized. Gene sequencing …

[PDF][PDF] Third-Generation Electronic Literature

L Flores - Electronic Literature as Digital Humanities, 2021 - library.oapen.org
Therefore, broader forms of communication, such as narrative, spoken and sign language,
audio and video recordings of performances, purely visual comics, and video games are of …

Targeted molecular-genetic imaging and ligand-directed therapy in aggressive variant prostate cancer

…, MM Alauddin, LG Flores… - Proceedings of the …, 2016 - National Acad Sciences
Aggressive variant prostate cancers (AVPC) are a clinically defined group of tumors of
heterogeneous morphologies, characterized by poor patient survival and for which limited …

[PDF][PDF] High-resolution SPECT to assess hippocampal perfusion in neuropsychiatric diseases

…, S Nagamachi, S Jinnouchi, LG Flores… - Journal of Nuclear …, 1995 - Soc Nuclear Med
A totalof 45 right-handedpatientswere Investigated (13 with dementia of Alzheimertype, 6 with
mum-infarctdementia, 4 wfthprogressivedementiawithmotorneurondisease (MND), 3 with …

Small-animal PET of tumor damage induced by photothermal ablation with 64Cu-bis-DOTA-hypericin

…, W Lu, Q Huang, G Ku, J Zhao, LG Flores… - Journal of Nuclear …, 2011 - Soc Nuclear Med
The purpose of this study was to investigate the potential application of small-molecular-weight
64 Cu-labeled bis-DOTA-hypericin in the noninvasive assessment of response to …

[HTML][HTML] Imaging epigenetic regulation by histone deacetylases in the brain using PET/MRI with 18F-FAHA

…, D Young, A Shavrin, U Mukhapadhyay, LG Flores… - NeuroImage, 2013 - Elsevier
Epigenetic modifications mediated by histone deacetylases (HDACs) play important roles in
the mechanisms of different neurologic diseases and HDAC inhibitors (HDACIs) have …