Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease
…, DLG Nelson, S Luecke, LA Phebus… - Proceedings of the …, 2001 - National Acad Sciences
Parkinson's disease is a chronic neurodegenerative disorder characterized by the loss of
dopamine neurons in the substantia nigra, decreased striatal dopamine levels, and …
dopamine neurons in the substantia nigra, decreased striatal dopamine levels, and …
Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortex
…, W Zhang, PA Carter, J Shaw, E Chernet, L Phebus… - …, 2002 - Springer
Rationale: The selective serotonin uptake inhibitor (SSRI) fluoxetine has been shown to not
only increase the extracellular concentrations of serotonin, but also dopamine and …
only increase the extracellular concentrations of serotonin, but also dopamine and …
Measurement of striatal H2O2 by microdialysis following global forebrain ischemia and reperfusion in the rat: correlation with the cytotoxic potential of H2O2 in vitro
PA Hyslop, Z Zhang, DV Pearson, LA Phebus - Brain research, 1995 - Elsevier
Toxic reactive oxygen species have been implicated as important mediators of tissue injury
after reperfusion of ischemic organs. When rats are subject to 30 min global forebrain …
after reperfusion of ischemic organs. When rats are subject to 30 min global forebrain …
Preclinical pharmacological profile of the selective 5-HT1F receptor agonist lasmiditan
DL Nelson, LA Phebus, KW Johnson… - …, 2010 - journals.sagepub.com
… The dural extravasation assay was modified from that previously described by Johnson and
Phebus (25). Male Wistar rats from Harlan Laboratories (250–350 g), fasted overnight, were …
Phebus (25). Male Wistar rats from Harlan Laboratories (250–350 g), fasted overnight, were …
Endocannabinoids activate transient receptor potential vanilloid 1 receptors to reduce hyperdopaminergia-related hyperactivity: therapeutic implications
…, L Moutsimilli, T Bisogno, V Di Marzo, LA Phebus… - Biological …, 2006 - Elsevier
… Lago et al 2004) and URB597 (a FAAH inhibitor inactive on TRPV1) reduces levodopa-induced
locomotion in the reserpine-treated rat also in a capsazepine-dependent manner (Lee et …
locomotion in the reserpine-treated rat also in a capsazepine-dependent manner (Lee et …
5-HT1F receptor agonists inhibit neurogenic dural inflammation in guinea pigs
…, JM Zgombick, ML Cohen, TA Branchek, LA Phebus - …, 1997 - journals.lww.com
THE serotonin (5-HT) receptor subtype mediating inhibition of neurogenic dural inflammation
in guinea pigs was investigated using a series of serotonin agonists with differing affinities …
in guinea pigs was investigated using a series of serotonin agonists with differing affinities …
Characterization of LY344864 as a pharmacological tool to study 5-HT1F receptors: binding affinities, brain penetration and activity in the neurogenic dural …
LA Phebus, KW Johnson, JM Zgombick, PJ Gilbert… - Life sciences, 1997 - Elsevier
LY344864 is a selective receptor agonist with an affinity of 6 nM (K i ) at the recently cloned
5-HT 1F receptor. It possesses little affinity for the 56 other serotonergic and non-…
5-HT 1F receptor. It possesses little affinity for the 56 other serotonergic and non-…
Imaging and quantitation of cannabinoid CB1 receptors in human and monkey brains using 18F-labeled inverse agonist radioligands
…, JT Tauscher, JM Schaus, L Phebus… - Journal of Nuclear …, 2010 - Soc Nuclear Med
We recently demonstrated that 11 C-MePPEP, a PET ligand for CB 1 receptors, has such high
uptake in the human brain that it can be imaged for 210 min and that receptor density can …
uptake in the human brain that it can be imaged for 210 min and that receptor density can …
Quantitation of cannabinoid CB1 receptors in healthy human brain using positron emission tomography and an inverse agonist radioligand
…, A Lerner, JT Tauscher, JM Schaus, L Phebus… - Neuroimage, 2009 - Elsevier
[ 11 C]MePPEP is a high affinity, CB 1 receptor-selective, inverse agonist that has been
studied in rodents and monkeys. We examined the ability of [ 11 C]MePPEP to quantify CB 1 …
studied in rodents and monkeys. We examined the ability of [ 11 C]MePPEP to quantify CB 1 …
[HTML][HTML] The PET radioligand [11C] MePPEP binds reversibly and with high specific signal to cannabinoid CB1 receptors in nonhuman primate brain
…, J Tauscher, JM Schaus, LA Phebus… - …, 2008 - nature.com
The cannabinoid CB 1 receptor is one of the most abundant G protein-coupled receptors in
the brain and is a promising target of therapeutic drug development. Success of drug …
the brain and is a promising target of therapeutic drug development. Success of drug …