Synthesis and Biological Evaluation of EC20: A New Folate-Derived, 99mTc-Based Radiopharmaceutical
A new peptide derivative of folic acid was designed to efficiently coordinate 99m Tc. This new
chelate, referred to as EC20, was found to bind cultured folate receptor (FR)-positive tumor …
chelate, referred to as EC20, was found to bind cultured folate receptor (FR)-positive tumor …
Folate‐targeted imaging of activated macrophages in rats with adjuvant‐induced arthritis
…, WR Widmer, CM Paulos, LC Xu… - … : Official Journal of …, 2002 - Wiley Online Library
Objective To determine whether overexpression of the high‐affinity folate receptor (FR) on
activated macrophages can be exploited to selectively target imaging agents to sites of …
activated macrophages can be exploited to selectively target imaging agents to sites of …
Preclinical Evaluation of EC145, a Folate-Vinca Alkaloid Conjugate
…, R Dorton, E Westrick, A Dawson, T Smith, LC Xu… - Cancer research, 2007 - AACR
We recently developed a new group of folate-conjugated Vinca alkaloids, one of which, EC145,
emerged as a candidate for clinical development. Brief treatment of nude mice bearing ∼…
emerged as a candidate for clinical development. Brief treatment of nude mice bearing ∼…
Preclinical evaluation of 99mTc-EC20 for imaging folate receptor–positive tumors
Our group previously reported on the synthesis and characterization of a novel 99m Tc-based
folate-peptide chelator called EC20. This agent was found to bind folate receptor (FR)–…
folate-peptide chelator called EC20. This agent was found to bind folate receptor (FR)–…
Synthesis and biological evaluation of EC72: a new folate-targeted chemotherapeutic
…, M Vetzel, N Parker, JS Nicoson, LC Xu… - Bioconjugate …, 2005 - ACS Publications
A novel folate conjugate of mitomycin C, herein referred to as EC72, was designed and
evaluated for biological activity against FR-positive cells and tumors. EC72 was produced by …
evaluated for biological activity against FR-positive cells and tumors. EC72 was produced by …
[HTML][HTML] Preclinical evaluation of bispecific adaptor molecule controlled folate receptor CAR-T cell therapy with special focus on pediatric malignancies
…, J Gustafson, N Parker, M Vetzel, LC Xu… - Frontiers in …, 2019 - frontiersin.org
Chimeric antigen receptor (CAR)-T cell therapy has transformed pediatric oncology by producing
high remission rates and potent effects in CD19+ B-cell malignancies. This scenario is …
high remission rates and potent effects in CD19+ B-cell malignancies. This scenario is …
[HTML][HTML] A universal dual mechanism immunotherapy for the treatment of influenza virus infections
Seasonal influenza epidemics lead to 3–5 million severe infections and 290,000–650,000
annual global deaths. With deaths from the 1918 influenza pandemic estimated at >…
annual global deaths. With deaths from the 1918 influenza pandemic estimated at >…
Folate receptor-β in activated macrophages: ligand binding and receptor recycling kinetics
Activated macrophages overexpress a receptor for the vitamin folic acid termed the folate
receptor β (FR-β). Because conjugation of folate to low molecular weight drugs, genes, …
receptor β (FR-β). Because conjugation of folate to low molecular weight drugs, genes, …
Preclinical pharmacokinetics, tissue distribution, and antitumor activity of a folate-hapten conjugate–targeted immunotherapy in hapten-immunized mice
Folic acid (pteroylglutamic acid) represents a useful ligand for targeted cancer therapies
because it binds to a common epithelial tumor antigen known as the folate receptor. We …
because it binds to a common epithelial tumor antigen known as the folate receptor. We …
Folate receptor-targeted aminopterin therapy is highly effective and specific in experimental models of autoimmune uveitis and autoimmune encephalomyelitis
…, TW Stinnette, JF Vaughn, SJ Hahn, LC Xu… - Clinical …, 2014 - Elsevier
EC0746 is a rationally designed anti-inflammatory drug conjugate consisting of a modified
folic acid-based ligand linked to a γ-hydrazide analog of aminopterin. In this report, EC0746's …
folic acid-based ligand linked to a γ-hydrazide analog of aminopterin. In this report, EC0746's …