Synthesis and Biological Evaluation of EC20:  A New Folate-Derived, 99mTc-Based Radiopharmaceutical

CP Leamon, MA Parker, IR Vlahov, LC Xu… - Bioconjugate …, 2002 - ACS Publications
A new peptide derivative of folic acid was designed to efficiently coordinate 99m Tc. This new
chelate, referred to as EC20, was found to bind cultured folate receptor (FR)-positive tumor …

Folate‐targeted imaging of activated macrophages in rats with adjuvant‐induced arthritis

…, WR Widmer, CM Paulos, LC Xu… - … : Official Journal of …, 2002 - Wiley Online Library
Objective To determine whether overexpression of the high‐affinity folate receptor (FR) on
activated macrophages can be exploited to selectively target imaging agents to sites of …

Preclinical Evaluation of EC145, a Folate-Vinca Alkaloid Conjugate

…, R Dorton, E Westrick, A Dawson, T Smith, LC Xu… - Cancer research, 2007 - AACR
We recently developed a new group of folate-conjugated Vinca alkaloids, one of which, EC145,
emerged as a candidate for clinical development. Brief treatment of nude mice bearing ∼…

Preclinical evaluation of 99mTc-EC20 for imaging folate receptor–positive tumors

JA Reddy, LC Xu, N Parker, M Vetzel… - Journal of Nuclear …, 2004 - Soc Nuclear Med
Our group previously reported on the synthesis and characterization of a novel 99m Tc-based
folate-peptide chelator called EC20. This agent was found to bind folate receptor (FR)–…

Synthesis and biological evaluation of EC72: a new folate-targeted chemotherapeutic

…, M Vetzel, N Parker, JS Nicoson, LC Xu… - Bioconjugate …, 2005 - ACS Publications
A novel folate conjugate of mitomycin C, herein referred to as EC72, was designed and
evaluated for biological activity against FR-positive cells and tumors. EC72 was produced by …

[HTML][HTML] Preclinical evaluation of bispecific adaptor molecule controlled folate receptor CAR-T cell therapy with special focus on pediatric malignancies

…, J Gustafson, N Parker, M Vetzel, LC Xu… - Frontiers in …, 2019 - frontiersin.org
Chimeric antigen receptor (CAR)-T cell therapy has transformed pediatric oncology by producing
high remission rates and potent effects in CD19+ B-cell malignancies. This scenario is …

[HTML][HTML] A universal dual mechanism immunotherapy for the treatment of influenza virus infections

…, B Zhang, Y Wang, HS Haymour, F Zhang, L Xu… - Nature …, 2020 - nature.com
Seasonal influenza epidemics lead to 3–5 million severe infections and 290,000–650,000
annual global deaths. With deaths from the 1918 influenza pandemic estimated at >…

Folate receptor-β in activated macrophages: ligand binding and receptor recycling kinetics

…, CM Paulos, J Reddy, LC Xu… - Molecular …, 2014 - ACS Publications
Activated macrophages overexpress a receptor for the vitamin folic acid termed the folate
receptor β (FR-β). Because conjugation of folate to low molecular weight drugs, genes, …

Preclinical pharmacokinetics, tissue distribution, and antitumor activity of a folate-hapten conjugate–targeted immunotherapy in hapten-immunized mice

Y Lu, LC Xu, N Parker, E Westrick, JA Reddy… - Molecular cancer …, 2006 - AACR
Folic acid (pteroylglutamic acid) represents a useful ligand for targeted cancer therapies
because it binds to a common epithelial tumor antigen known as the folate receptor. We …

Folate receptor-targeted aminopterin therapy is highly effective and specific in experimental models of autoimmune uveitis and autoimmune encephalomyelitis

…, TW Stinnette, JF Vaughn, SJ Hahn, LC Xu… - Clinical …, 2014 - Elsevier
EC0746 is a rationally designed anti-inflammatory drug conjugate consisting of a modified
folic acid-based ligand linked to a γ-hydrazide analog of aminopterin. In this report, EC0746's …