Rapid decay of engulfed extracellular miRNA by XRN1 exonuclease promotes transient epithelial-mesenchymal transition

J Zangari, M Ilie, F Rouaud, L Signetti… - Nucleic acids …, 2017 - academic.oup.com
Extracellular vesicles (EVs) have been shown to play an important role in intercellular
communication as carriers of DNA, RNA and proteins. While the intercellular transfer of miRNA …

Targeting the multidrug transporter Patched potentiates chemotherapy efficiency on adrenocortical carcinoma in vitro and in vivo

…, C Ruggiero, S Jung, I Rapa, L Signetti… - … journal of cancer, 2018 - Wiley Online Library
One of the crucial challenges in the clinical management of cancer is the resistance to
chemotherapeutics. We recently demonstrated that the Hedgehog receptor Patched, which is …

[HTML][HTML] Inhibition of Patched Drug Efflux Increases Vemurafenib Effectiveness against Resistant BrafV600E Melanoma

L Signetti, N Elizarov, M Simsir, A Paquet, D Douguet… - Cancers, 2020 - mdpi.com
Melanoma patients harboring the BRAF V600E mutation are treated with vemurafenib. Almost
all of them ultimately acquire resistance, leading to disease progression. Here, we find …

[HTML][HTML] Methiothepin increases chemotherapy efficacy against resistant melanoma cells

N Durand, M Simsir, L Signetti, F Labbal, R Ballotti… - Molecules, 2021 - mdpi.com
We previously reported that methiothepin, a small molecule known as a nonselective
serotonin 5-HT receptor antagonist, inhibited the doxorubicin efflux activity of the Hedgehog …

Iodinated contrast agents perturb iodide uptake by the thyroid independently of free iodide

G Vassaux, C Zwarthoed, L Signetti… - Journal of Nuclear …, 2018 - Soc Nuclear Med
Perturbation of thyroid iodide uptake is a well-documented side effect of the use of iodinated
contrast media (ICM) administered intravenously. This side effect is thought to be mediated …

The oncogenic tyrosine kinase Lyn impairs the pro-apoptotic function of Bim

LE Aira, E Villa, P Colosetti, P Gamas, L Signetti… - Oncogene, 2018 - nature.com
Phosphorylation of Ser/Thr residues is a well-established modulating mechanism of the pro-apoptotic
function of the BH3-only protein Bim. However, nothing is known about the …

Rapid decay of engulfed extracellular miRNA by XRN1 exonuclease promotes transient epithelial-mesenchymal transition

J Zangari, M Ilie, F Rouaud, L Signetti… - Nucleic Acids …, 2018 - ncbi.nlm.nih.gov
In the published Figure 1, the panels D, E and F were inverted. Panel D should be panel F,
E should be D, and F should be E. In addition, the scales of the vertical axis in panels C, D …

The role of TRF2 on tumor progression in non-small cell lung cancer: potential modulating effect on myeloid cells

L Bouhlel, M Ilie, L Signetti, J Cherfils-Vicini, E Selva… - Cancer Research, 2016 - AACR
Background: TRF2 is a key factor involved in telomere protection and has been found to be
upregulated in various human cancers. The recent discovery by which TRF2 inhibits …

Impact of Kras mutant subtypes on PD-L1 expression in lung adenocarcinoma

M Ilie, L Fazzalari, N Guibert, N Yazbeck, L Signetti… - Cancer Research, 2016 - AACR
Clinical responses to immune checkpoint blockade by anti-PD-1/PD-L1 monoclonal antibodies
in non-small-cell lung cancer (NSCLC) may be associated with PD-L1 expression. This …

[PDF][PDF] The multiple facets of RNA in development and disease

E Bertrand, L Colleaux, A Dziembowski, RF de Luco… - 2018 - signalife.univ-cotedazur.fr
MicroRNAs are small non-coding RNAs that can base-pair to specific mRNAs, and thereby
function, in association with an Argonaute partner protein, as post-transcriptional regulators …