Neuromyelitis optica (NMO) is an inflammatory and demyelinating disease of the central
nervous system. Although the prevalence of NMO is low, the rapid and severe impairment …

Plasma 5-hydroxytryptamine (5-HT; serotonin), released from blood platelets, plays a major
role in the human cardiovascular system. Besides the effect of endogenous serotonin, many …

Serotonergic dysfunction is mainly associated with neuropsychiatric and cardiovascular
disorders but has also been linked with many other pathological conditions. Serotonin (5-…

Cardiac failure is the most common cause of mortality in Friedreich's ataxia (FRDA), a
mitochondrial disease characterized by neurodegeneration, hypertrophic cardiomyopathy and …

The function of the majority of genes in the mouse and human genomes remains unknown.
The mouse embryonic stem cell knockout resource provides a basis for the characterization …

Background—Identification of factors regulating myocardial structure and function is
important to understand the pathogenesis of heart disease. Because little is known about the …

By mimicking sympathetic stimulation in vivo, we previously reported that mice globally
lacking serotonin 5-HT 2B receptors did not develop isoproterenol-induced left ventricular …

Background— Identification of factors regulating myocardial structure and function is important
to understand the pathogenesis of heart disease. We previously reported that 5-HT 2B …

Background— The serotonergic 5-HT 2B receptor regulates cardiomyocyte development and
growth. A putative contribution of this receptor to fibroblast-dependent cardiac function has …

Friedreich ataxia (FRDA), a progressive neurodegenerative disorder associated with
cardiomyopathy, is caused by severely reduced frataxin, a mitochondrial protein involved in Fe-S …