Previous studies have identified a crucial role of the gut microbiome in modifying Alzheimer’s
disease (AD) progression. However, the mechanisms of microbiome–brain interaction in …

Coding variants in the triggering receptor expressed on myeloid cells 2 (TREM2) are associated
with late-onset Alzheimer’s disease (AD). We demonstrate that amyloid plaque seeding …

Microglia appear activated in the vicinity of amyloid beta (Aβ) plaques, but whether microglia
contribute to Aβ propagation into unaffected brain regions remains unknown. Using …

Transcriptome analysis of somatic stem cells and their progeny is fundamental to identify
new factors controlling proliferation versus differentiation during tissue formation. Here, we …

Microglial dysfunction is a key pathological feature of Alzheimer's disease (AD), but little is
known about proteome-wide changes in microglia during the course of AD and their …

Microglia adopt numerous fates with homeostatic microglia ( HM ) and a microglial
neurodegenerative phenotype ( MG nD) representing two opposite ends. A number of variants in …

To understand how cells communicate in the nervous system, it is essential to define their
secretome, which is challenging for primary cells because of large cell numbers being required…

Niemann-Pick type C disease is a rare neurodegenerative disorder mainly caused by
mutations in NPC1, resulting in abnormal late endosomal/lysosomal lipid storage. Although …

Introduction Murine microglia expressing the Alzheimer's disease–linked TREM2 R47H
mutation display variable decrease in phagocytosis, while impaired phagocytosis is reported …

Alzheimer’s disease (AD) is the most common age-related neurodegenerative disorder.
Increased Aβ production plays a fundamental role in the pathogenesis of the disease and …