Purpose: Up to 30% of patients with breast cancer relapse after primary treatment. There
are no sensitive and reliable tests to monitor these patients and detect distant metastases …

The integrin α v β 3 receptor is upregulated on tumor cells and endothelium and plays
important roles in angiogenesis and metastasis. Arg-Gly-Asp (RGD) peptide ligands have high …

Purpose 3′-Deoxy-3′-[ 18 F]fluorothymidine positron emission tomography ([ 18 F]FLT-PET)
has been developed for imaging cell proliferation and findings correlate strongly with the …

There is an unmet need to develop imaging methods for the early and objective assessment
of breast tumors to therapy. 3′-Deoxy-3′-[ 18 F]fluorothymidine ([ 18 F]FLT)–positron …

Purpose: To evaluate the accuracy and biological basis for [ 11 C]choline-PET-CT in the
nodal staging of high risk localized prostate cancer patients. Experimental Design: Twenty-eight …

Resistance to 5-Fluoruracil (5-FU) has been linked to elevated expression of the main target,
thymidylate synthase (TYMS), which catalyses the de novo pathway for production of …

The objective of this study was to establish the repeatability and reproducibility limits of
several volume-related PET image–derived indices—namely tumor volume (TV), mean …

FOXM1 is implicated in genotoxic drug resistance but its role and mechanism of action
remain unclear. Here, we establish that γH2AX foci, indicative of DNA double-strand breaks (…

Cognitive impairment is a debilitating side effect experienced by patients with cancer treated
with systemically administered anticancer therapies. With around 19.3 million new cases of …

Objective: Anticoagulation with heparin is standard of care for patients maintained on
extracorporeal life support. Very limited evidence exists for the use of alternative anticoagulants …