11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) has been proposed as a new target
for type 2 diabetes drugs. The aim of the present study was to assess the effects of inhibition …

Novel antidiabetic arylsulfonamidothiazoles are presented that exert action through selective
inhibition of the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme, thereby …

We describe the development of a novel serum albumin binding protein showing an
extremely high affinity (K D ) for HSA in the femtomolar range. Using a naturally occurring 46-…

The human epidermal growth factor receptor 2 (HER2) is specifically overexpressed in tumors
of several cancers, including an aggressive form of breast cancer. It is therefore a target …

The therapeutic and diagnostic efficiency of engineered small proteins, peptides, and
chemical drug candidates is hampered by short in vivo serum half-life. Thus, strategies to tailor …

The Affibody molecule Z HER2:342-pep2 , site-specifically and homogeneously conjugated
with a 1,4,7,10-tetra-azacylododecane-N,N′,N″,N‴-tetraacetic acid (DOTA) chelator, was …

Affibody molecules are non-immunoglobulin-derived affinity proteins based on a three-helical
bundle protein domain. Here, we describe the design process of an optimized Affibody …

Targeting radionuclide imaging of tumor-associated antigens may help to select patients who
will benefit from a particular biological therapy. Affibody ® molecules are a novel class of …

The detection of human epidermal growth factor receptor type 2 (HER2) expression in
malignant tumors provides important information influencing patient management. Radionuclide …

Detection of HER2-overexpression in tumors and metastases is important for the selection
of patients who will benefit from trastuzumab treatment. Earlier investigations showed …