Physiologic basis for assessing critical coronary stenosis: instantaneous flow response and regional distribution during coronary hyperemia as measures of coronary …

KL Gould, K Lipscomb, GW Hamilton - The American journal of cardiology, 1974 - Elsevier
Quantitative hemodynamic assessment of coronary stenosis has not been previously
reported. Resting coronary blood flow and its regional distribution are insensitive indexes for …

[HTML][HTML] Coronary flow reserve as a physiologic measure of stenosis severity

KL Gould, RL Kirkeeide, M Buchi - Journal of the American College of …, 1990 - Elsevier
PART I: Coronary flow reserve indicates functional stenosis severity, but may be altered by
physiologic conditions unrelated to stenosis geometry. To assess the effects of changing …

Intensive lifestyle changes for reversal of coronary heart disease

D Ornish, LW Scherwitz, JH Billings, KL Gould… - Jama, 1998 - jamanetwork.com
Context.—The Lifestyle Heart Trial demonstrated that intensive lifestyle changes may lead to
regression of coronary atherosclerosis after 1 year.Objectives.—To determine the feasibility …

Effects of coronary stenoses on coronary flow reserve and resistance

KL Gould, K Lipscomb - The American journal of cardiology, 1974 - Elsevier
Resting coronary flow and regional distribution are not affected by narrowing of up to 85
percent of arterial diameter and therefore provide little insight into the effects of stenoses on …

Effects of acute alcohol intoxication on cerebral blood flow measured with PET

ND Volkow, N Mullani, L Gould, SS Adler, RW Guynn… - Psychiatry …, 1988 - Elsevier
Regional distribution of cerebral blood flow was assessed in a group of 13 normal social
drinkers under baseline conditions and after acute alcohol intoxication. Blood flow …

Experimental basis of determining maximum coronary, myocardial, and collateral blood flow by pressure measurements for assessing functional stenosis severity …

…, JA Van Son, RL Kirkeeide, B De Bruyne, KL Gould - Circulation, 1993 - Am Heart Assoc
BACKGROUND Severity of coronary artery stenosis has been defined in terms of geometric
dimensions, pressure gradient-flow relations, resistance to flow and coronary flow reserve, …

Abnormal epicardial coronary resistance in patients with diffuse atherosclerosis but “normal” coronary angiography

…, J Bartunek, JW Bech, GR Heyndrickx, KL Gould… - Circulation, 2001 - Am Heart Assoc
Background Coronary arteries without focal stenosis at angiography are generally considered
non–flow-limiting. However, atherosclerosis is a diffuse process that often remains …

Anatomic versus physiologic assessment of coronary artery disease: role of coronary flow reserve, fractional flow reserve, and positron emission tomography imaging …

KL Gould, NP Johnson, TM Bateman… - Journal of the American …, 2013 - jacc.org
Angiographic severity of coronary artery stenosis has historically been the primary guide to
revascularization or medical management of coronary artery disease. However, physiologic …

Mechanism of the effect of coronary artery stenosis on coronary flow in the dog

K Lipscomb, KL Gould - American Heart Journal, 1975 - Elsevier
The hemodynamic mechanism of the effect of coronary artery stenosis on coronary flow was
studied in the circumflex artery of 10 open-chest dogs by simultaneously measuring …

Deep vein thrombosis and pulmonary embolism in head injured patients

…, BJ McConnell, B Costin, A Borit, L Gould… - …, 1983 - journals.sagepub.com
Introduction It is well known that deep vein thrombosis (DVT) and secondary pulmo-nary
embolism (PE) are relatively common and significant complications in hospitalized patients. A …