Synthesis and radiolabeling of chelator–RNA aptamer bioconjugates with copper-64 for targeted molecular imaging

WM Rockey, L Huang, KC Kloepping… - Bioorganic & medicinal …, 2011 - Elsevier
Ribonucleic acid (RNA) aptamers with high affinity and specificity for cancer-specific cell-surface
antigens are promising reagents for targeted molecular imaging of cancer using …

[HTML][HTML] Triphenylphosphonium derivatives disrupt metabolism and inhibit melanoma growth in vivo when delivered via a thermosensitive hydrogel

KC Kloepping, AS Kraus, DK Hedlund, CM Gnade… - PloS one, 2020 - journals.plos.org
Despite dramatic improvements in outcomes arising from the introduction of targeted therapies
and immunotherapies, metastatic melanoma is a highly resistant form of cancer with 5 …

Improved synthesis and biological evaluation of chelator-modified α-MSH analogs prepared by copper-free click chemistry

…, SG Parameswarappa, KC Kloepping… - Bioorganic & medicinal …, 2011 - Elsevier
Radionuclide chelators (DOTA, NOTA) functionalized with a monofluorocyclooctyne group
were prepared. These materials reacted rapidly and in high yield with a fully deprotected …

Sensitivity and isoform specificity of 18F-fluorofuranylnorprogesterone for measuring progesterone receptor protein response to estradiol challenge in breast cancer

…, Y Yan, JJ Jeffery, KC Kloepping… - Journal of Nuclear …, 2019 - Soc Nuclear Med
The purpose of this study was to evaluate the ability of 21- 18 F-fluoro-16α,17α-[(R)-(1′-α-furylmethylidene)dioxy]-19-norpregn-4-ene-3,20-dione
( 18 F-FFNP) to measure alterations in …

[BOOK][B] “Click”-Cyclized 68Ga-Labeled Peptides for Molecular Imaging and Therapy: Synthesis and Preliminary In Vitro and In Vivo Evaluation in a Melanoma Model …

…, M Sue O'Dorisio, WM Leverich, KC Kloepping… - 2013 - Springer
Cyclization techniques are used often to impart higher in vivo stability and binding affinity to
peptide targeting vectors for molecular imaging and therapy. The two most often used …

[HTML][HTML] Determination of binding affinity of molecular imaging agents for steroid hormone receptors in breast cancer

K Salem, M Kumar, KC Kloepping… - American Journal of …, 2018 - ncbi.nlm.nih.gov
… Radiolabeling was performed at 85C for 5 min. After mixing with a pre-cooled (5C) solution
of 1 mL acetonitrile and 2 mL H 2 O, the crude product was purified with HPLC with a Luna …

[PDF][PDF] Mitochondria-targeted therapy for metastatic melanoma

KC Kloepping - 2015 - iro.uiowa.edu
… by Kyle Christopher Kloepping … There were no differences in hepatitis C RNA viral load
levels, which argues that MitoQ affects hepatitis C virus mediated liver damage and not the virus …

[CITATION][C] 303-Triphenylphosphonium Derivative-Based Combination Therapy for Metastatic Melanoma

KC Kloepping, AS Kraus, DK Hedlund… - Free radical biology & …, 2014 - iro.uiowa.edu

[CITATION][C] Small Molecule Oxidative Metabolism Inhibitors for Metastatic Melanoma Therapy

KC Kloepping, MC Coleman, BA Wagner… - Free radical biology & …, 2012 - iro.uiowa.edu

Collaborative Undergraduate HBCU Student Summer Training Program Award

DM Lubaroff, IOWA UNIV IOWA CITY - 2011 - apps.dtic.mil
… We will use prostate-specifi c antigen (PSA), a protei n known to be aberran tly expressed
in prostate cancer, as a target for immunotherapy of prostate cancer. In fact, PSA has been …