Hyperthermia is under intensive investigation as a treatment for tumors both alone and in
combination with other therapeutic agents. Hyperthermia has a profound effect on the function …

Glycerol and D 2 O can provide a protective effect to Chinese hamster V79 cells receiving
heat treatment. The mechanism for this effect is assumed to be the ability of these agents to …

We previously showed a significant enhancement of tirapazamineinduced cytotoxicity and
DNA damage after binding with copper. This result suggests that conjugates of tirapazamine …

Tirapazamine (Tira), a bioreductive agent, is highly toxic to cells under low oxygen conditions.
Since active investigations of this agent are focusing on its potential as an adjunct of …

Several methods of establishing low O 2 conditions have been used in studies on the
response of cultured cells to radiation and other agents. These methods, eg, gassing culture …

Mammalian erythrocytes that lack cytoplasmic organelles and a nucleus are a useful model
for studying the effect of heat on the cell membrane and cytoskeleton. The effect of heat on …

A metal chelator, diethyldithiocarbamate (DDC) perturbs the chromosome condensation
processes in dividing cells. The length of the metaphase chromosomes in Chinese hamster …

Chinese hamster V79 cells were used to test the cytotoxic effect of heat which alternates
between high and low temperatures during the treatment period. This type of temperature …

Tirapazamine (Tira, SR 4233), a Bioreductive agent, is highly toxic to cells under low oxygen
conditions because it produces a toxic oxidizing radical intermediate. The mechanisms for …

The Escherichia coli lacZ gene, which codes bacterial β-galactosidase (β-gal), is one of the
commonly used reporter genes (1). The popularity of this reporter gene system stems from …