User profiles for Kuo-Shyan Lin
 | Kuo-Shyan LinBC Cancer Agency Verified email at bccrc.ca Cited by 4111 |
Enhancing Treatment Efficacy of 177Lu-PSMA-617 with the Conjugation of an Albumin-Binding Motif: Preclinical Dosimetry and Endoradiotherapy Studies
We designed and evaluated a novel albumin-binder-conjugated 177 Lu-PSMA-617 derivative,
177 Lu-HTK01169, with an extended blood retention time to maximize the radiation dose …
177 Lu-HTK01169, with an extended blood retention time to maximize the radiation dose …
Bench to bedside: albumin binders for improved cancer radioligand therapies
Radioligand therapy (RLT) relies on the use of pharmacophores to selectively deliver
ionization energy to cancers to exert its tumoricidal effects. Cancer cells that are not directly …
ionization energy to cancers to exert its tumoricidal effects. Cancer cells that are not directly …
225Ac-H4py4pa for Targeted Alpha Therapy
…, V Radchenko, P Schaffer, KS Lin… - Bioconjugate …, 2020 - ACS Publications
Herein, we present the syntheses and characterization of a new undecadendate chelator, H
4 py4pa, and its bifunctional analog H 4 py4pa-phenyl-NCS, conjugated to the monoclonal …
4 py4pa, and its bifunctional analog H 4 py4pa-phenyl-NCS, conjugated to the monoclonal …
Overcoming the hypoxic barrier to radiation therapy with anaerobic bacteria
…, JM McCaffery, EL Watson, KS Lin… - Proceedings of the …, 2003 - National Acad Sciences
The low level of oxygenation within tumors is a major cause of radiation treatment failures.
We theorized that anaerobic bacteria that can selectively destroy the hypoxic regions of …
We theorized that anaerobic bacteria that can selectively destroy the hypoxic regions of …
An Organotrifluoroborate for Broadly Applicable One‐Step 18F‐Labeling
A new zwitterionic organotrifluoroborate is appended to three radiosynthons that afford
undergo facile bioconjugation to several clinically relevant peptides and one enzyme inhibitor. …
undergo facile bioconjugation to several clinically relevant peptides and one enzyme inhibitor. …
Preclinical evaluation of a high-affinity 18F-trifluoroborate octreotate derivative for somatostatin receptor imaging
Recent studies have highlighted the high sensitivity of PET imaging with 68 Ga-labeled
octreotide derivatives for the detection and staging of neuroendocrine tumors. A somatostatin …
octreotide derivatives for the detection and staging of neuroendocrine tumors. A somatostatin …
[HTML][HTML] Insight into the Development of PET Radiopharmaceuticals for Oncology
While the development of positron emission tomography (PET) radiopharmaceuticals closely
follows that of traditional drug development, there are several key considerations in the …
follows that of traditional drug development, there are several key considerations in the …
One-step 18F labeling of biomolecules using organotrifluoroborates
Herein we present a general protocol for the functionalization of biomolecules with an
organotrifluoroborate moiety so that they can be radiolabeled with aqueous 18 F fluoride ( 18 F − ) …
organotrifluoroborate moiety so that they can be radiolabeled with aqueous 18 F fluoride ( 18 F − ) …
Design, synthesis, and initial evaluation of high-affinity technetium bombesin analogues
KE Baidoo, KS Lin, Y Zhan, P Finley… - Bioconjugate …, 1998 - ACS Publications
Potent antagonists of bombesin-like peptides have shown great potential for applications in
cancer therapy. A 99m Tc-labeled agent capable of identifying patients who could benefit …
cancer therapy. A 99m Tc-labeled agent capable of identifying patients who could benefit …
Imaging the Cannabinoid CB1 Receptor in Humans with [11C] OMAR: Assessment of Kinetic Analysis Methods, Test–Retest Reproducibility, and Gender Differences
The Radiotracer [ 11 C]OMAR was developed for positron emission tomography (PET)
imaging of cannabinoid type-1 receptors (CB1R). The objectives of the present study were to …
imaging of cannabinoid type-1 receptors (CB1R). The objectives of the present study were to …