[HTML][HTML] Erianthridin suppresses non-small-cell lung cancer cell metastasis through inhibition of Akt/mTOR/p70S6K signaling pathway

S Pothongsrisit, K Arunrungvichian, Y Hayakawa… - Scientific Reports, 2021 - nature.com
Cancer metastasis is a major cause of the high mortality rate in lung cancer patients. The
cytoskeletal rearrangement and degradation of extracellular matrix are required to facilitate cell …

Relationships between amyloid levels, glucose metabolism, morphologic changes in the brain and clinical status of patients with Alzheimer's disease

…, O Chawalparit, K Arunrungvichian… - Annals of Nuclear …, 2020 - Springer
Objective The current study was conducted to improve the understanding of relationships
between regional cortical amyloid load, glucose metabolism, cortical morphology (volume), …

Targeting Alpha7 Nicotinic Acetylcholine Receptors in Lung Cancer: Insights, Challenges, and Therapeutic Strategies

K Arunrungvichian, O Vajragupta… - ACS Pharmacology & …, 2023 - ACS Publications
Alpha7 nicotinic acetylcholine receptor (α7 nAChR) is an ion-gated calcium channel that
plays a significant role in various aspects of cancer pathogenesis, particularly in lung cancer. …

Selectivity optimization of substituted 1, 2, 3-triazoles as α7 nicotinic acetylcholine receptor agonists

K Arunrungvichian, VV Fokin… - ACS Chemical …, 2015 - ACS Publications
Three series of substituted anti-1,2,3-triazoles (IND, PPRD, and QND), synthesized by
cycloaddition from azide and alkyne building blocks, were designed to enhance selectivity and …

α7-Nicotinic acetylcholine receptor antagonist QND7 suppresses non-small cell lung cancer cell proliferation and migration via inhibition of Akt/mTOR signaling

W Witayateeraporn, K Arunrungvichian… - Biochemical and …, 2020 - Elsevier
Lung cancer, one of the most commonly found carcinoma type, has the highest mortality rate
in cancer patients worldwide. Therapeutic interventions targeting to lung cancer become …

[HTML][HTML] Selective α3β4 Nicotinic Acetylcholine Receptor Ligand as a Potential Tracer for Drug Addiction

…, O Vajragupta, K Arunrungvichian - International Journal of …, 2023 - mdpi.com
α 3 β 4 Nicotinic acetylcholine receptor (nAChR) has been recognized as an emerging biomarker
for the early detection of drug addiction. Herein, α 3 β 4 nAChR ligands were designed …

Cognitive improvements in a mouse model with substituted 1, 2, 3-triazole agonists for nicotinic acetylcholine receptors

K Arunrungvichian, C Boonyarat, VV Fokin… - ACS Chemical …, 2015 - ACS Publications
The α7 nicotinic acetylcholine receptor (nAChR) is a recognized drug target for dementias
of aging and certain developmental disorders. Two selective and potent α7-nAChR agonists, …

Varying chirality across nicotinic acetylcholine receptor subtypes: selective binding of quinuclidine triazole compounds

…, W Parichatikanond, K Arunrungvichian… - ACS Medicinal …, 2016 - ACS Publications
The novel quinuclidine anti-1,2,3-triazole derivatives T1–T6 were designed based on the
structure of QND8. The binding studies revealed that the stereochemistry at the C3 position of …

Implementation of [18F]-labeled amyloid brain PET imaging biomarker in the diagnosis of Alzheimer's disease: first-hand experience in Thailand

…, O Chawalparit, K Arunrungvichian… - Nuclear Medicine …, 2018 - journals.lww.com
Assessment of Aβ plaque deposition in the brain using PET imaging is a well-validated
biomarker for the diagnosis of AD at the preclinical and prodomal stage. Furthermore, PET …

[PDF][PDF] Inhibitory effects of Triphala on CYP isoforms in vitro and its pharmacokinetic interactions with phenacetin and midazolam in rats

…, P Siripong, H Sato, S Chewchinda, K Arunrungvichian… - Heliyon, 2022 - cell.com
Context Direct evidence of Triphala-drug interactions has not been provided to date.
Objective This study was aimed to determine the effects of Triphala on cytochrome P450 (CYP) …