[HTML][HTML] [18F]Nifene PET/CT Imaging in Mice: Improved Methods and Preliminary Studies of α4β2* Nicotinic Acetylcholinergic Receptors in Transgenic A53T Mouse …

ADT Campoy, C Liang, RM Ladwa, KK Patel, IH Patel… - Molecules, 2021 - mdpi.com
We report [ 18 F]nifene binding to α4β2* nicotinic acetylcholinergic receptors (nAChRs) in
Parkinson’s disease (PD). The study used transgenic Hualpha-Syn(A53T) PD mouse model of …

[HTML][HTML] Comparison of Monoamine Oxidase-A, Aβ Plaques, Tau, and Translocator Protein Levels in Postmortem Human Alzheimer's Disease Brain

AU Syed, C Liang, KK Patel, R Mondal… - International journal of …, 2023 - mdpi.com
Increased monoamine oxidase-A (MAO-A) activity in Alzheimer’s disease (AD) may be
detrimental to the point of neurodegeneration. To assess MAO-A activity in AD, we compared four …

Development and evaluation of [125I]IPPI for Tau imaging in postmortem human Alzheimer's disease brain

J Mukherjee, C Liang, KK Patel, PQ Lam, R Mondal - Synapse, 2021 - Wiley Online Library
Objective: Alzheimer's disease (AD) is a neurodegenerative disease characterized by
aggregation of Tau protein into paired helical filaments causing neurofibrillary tangles (NFT) in the …

[HTML][HTML] Synthesis and Evaluation of Compound Targeting α7 and β2 Subunits in Nicotinic Acetylcholinergic Receptor

K Singh, A Ngo, OV Keerthisinghe, KK Patel, C Liang… - Molecules, 2023 - mdpi.com
Nicotinic acetylcholine receptors (nAChRs) are involved in various central nervous system
functions and have also been implicated in several neurodegenerative disorders. The …

Monoamine oxidase-A is upregulated in post-mortem human Alzheimer's disease and Parkinson's disease brain

…, A Syed, P Lam, R Mondal, T Mukherjee, K Patel - 2021 - Soc Nuclear Med
1609 Objectives: Monoamine oxidases play a significant role in the pathogenesis of
neurodegeneration. The role of the brain isozyme, MAO-A in neurodegeneration is less known. We …

Upregulation of Nicotinic Acetylcholinergic Receptors in Human Lung Adenocarcinomas

K Patel, E Karanjah, N Ghazaryan, S Loomba, G Samra… - 2019 - Soc Nuclear Med
1406 Objectives: Development of novel and more sensitive methods for early diagnosis of
lung cancer may be based on visualizing upregulated nicotinic acetylcholinergic receptors (…

Reduction in Nicotinic Receptors in Anterior Cingulate of Postmortem Human Alzheimer's Disease and Parkinson's Disease Brain

N Ghazaryan, K Patel, G Samra, J Mukherjee - 2019 - Soc Nuclear Med
1305 Objectives: Anterior cingulate in the human brain is innervated with nicotinic
acetylcholinergic receptors (nAChRs) α4β2[asterisk] in the human brain. This receptor system is …

[18F] FAZIN3: A novel PET imaging agent for Parkinson's Disease

P Lam, S Martinez, K Patel, C Liang, J Mukherjee - 2020 - Soc Nuclear Med
148 Objectives: Parkinsonian disorders may be either synucleinopathies or taupathies
based on neuropathological characteristics. In an effort to develop PET imaging agents for …

[18F] Nifene binding to Nicotinic α4β2* Receptors in Anterior Cingulate of Postmortem Human Alzheimer's Disease Brain

A Campoy, T Danh, K Patel, H Kaur, C Liang… - 2020 - Soc Nuclear Med
1537 Objectives: Anterior cingulate (AC) in the human brain is innervated with nicotinic α4β2*
receptors in the human brain. This receptor system is involved in cognition, learning and …

[CITATION][C] Increased Tau, Aβ Amyloid, and Monoamine Oxidase-A in Post-Mortem Human Alzheimer's Disease Anterior Cingulate

…, C Liang, T Mukherjee, K Patel… - JOURNAL OF …, 2021 - SAGE PUBLICATIONS INC 2455 …