[PDF][PDF] Single-cell analyses inform mechanisms of myeloid-targeted therapies in colon cancer

…, J Kang, D Bhatt, D Lu, CM Li, AS Rapaport, K Perez… - Cell, 2020 - cell.com
Single-cell RNA sequencing (scRNA-seq) is a powerful tool for defining cellular diversity in
tumors, but its application toward dissecting mechanisms underlying immune-modulating …

CB-6644 is a selective inhibitor of the RUVBL1/2 complex with anticancer activity

…, K Lou, B Yao, MK Menon, A Pios, KC Perez… - ACS chemical …, 2019 - ACS Publications
RUVBL1 and RUVBL2 are ATPases associated with diverse cellular activities (AAAs) that form
a complex involved in a variety of cellular processes, including chromatin remodeling and …

STARTRAC analyses of scRNAseq data from tumor models reveal T cell dynamics and therapeutic targets

D Bhatt, B Kang, D Sawant, L Zheng, K Perez… - Journal of Experimental …, 2021 - rupress.org
Single-cell RNA sequencing is a powerful tool to examine cellular heterogeneity, novel
markers and target genes, and therapeutic mechanisms in human cancers and animal models. …

[HTML][HTML] Aberrantly elevated Wnt signaling is responsible for cementum overgrowth and dental ankylosis

Y Wu, X Yuan, KC Perez, S Hyman, L Wang… - Bone, 2019 - Elsevier
Vertebrate teeth are attached to the jawbones using a variety of methods but in mammals, a
fibrous connection is the norm. This fibrous periodontal ligament (PDL) allows teeth to move …

[HTML][HTML] Initial In Vivo Quantification of Tc-99m Sestamibi Uptake as a Function of Tissue Type in Healthy Breasts Using Dedicated Breast SPECT-CT

SD Mann, KL Perez, EKE McCracken, JP Shah… - Journal of …, 2012 - hindawi.com
A pilot study is underway to quantify in vivo the uptake and distribution of Tc-99m Sestamibi
in subjects without previous history of breast cancer using a dedicated SPECT-CT breast …

Cleft palate and Aglossia result from perturbations in Wnt and hedgehog signaling

G Yuan, G Singh, S Chen, KC Perez… - The Cleft Palate …, 2017 - journals.sagepub.com
Objective The objective of this study was to explore the molecular basis for cleft secondary
palate and arrested tongue development caused by the loss of the intraflagellar transport …

Towards quantification of functional breast images using dedicated SPECT with non-traditional acquisition trajectories

KL Perez, SJ Cutler, P Madhav… - IEEE transactions on …, 2011 - ieeexplore.ieee.org
Quantification of radiotracer uptake in breast lesions can provide valuable information to
physicians in deciding patient care or determining treatment efficacy. Physical processes (eg, …

[HTML][HTML] Hormone sensitive lipase ablation promotes bone regeneration

…, J Chen, M Wosczyna, BJR Salmon, KC Perez… - … et Biophysica Acta (BBA …, 2022 - Elsevier
There is an inverse relationship between the differentiation of mesenchymal stem cells (MSCs)
along either an adipocyte or osteoblast lineage, with lineage differentiation known to be …

[HTML][HTML] Generation of bone marrow chimeras using X-ray irradiation: comparison to cesium irradiation and use in immunotherapy

J Eng, J Orf, K Perez, D Sawant… - Journal of Biological …, 2020 - ncbi.nlm.nih.gov
Bone marrow chimeras represent a key tool employed to understand biological contributions
stemming from the hematopoietic versus the stromal compartment. In most institutions, …

Comparison of reduced angle and fully 3D acquisition sequencing and trajectories for dual-modality mammotomography

SJ Cutler, P Madhav, KL Perez… - 2007 IEEE Nuclear …, 2007 - ieeexplore.ieee.org
A dual-modality SPECT-CT system for dedicated 3D breast cancer imaging is under development.
Independent dedicated SPECT and CT imaging systems have been integrated onto a …